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  1. Article

    Open Access

    Pangenome analysis of Shewanella xiamenensis revealed important genetic traits concerning genetic diversity, pathogenicity and antibiotic resistance

    Shewanella xiamenensis, widely distributed in natural environments, has long been considered as opportunistic pathogen. Recently, significant changes in the resistance spectrum have been observed in S. xiamenens...

    Haichen Wang, Fengjun **a, Yubing **a, Jun Li, Yongmei Hu, Yating Deng in BMC Genomics (2024)

  2. Article

    Open Access

    Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China

    Recently, extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates have been increasingly detected and posed great challenges to clinical anti-infection treatments. However, little is known about exten...

    Jun Li, Mengli Tang, Zhaojun Liu, Yuhan Wei in Annals of Clinical Microbiology and Antimi… (2024)

  3. Article

    Open Access

    Parton labeling without matching: unveiling emergent labelling capabilities in regression models

    Parton labeling methods are widely used when reconstructing collider events with top quarks or other massive particles. State-of-the-art techniques are based on machine learning and require training data with ...

    Shikai Qiu, Shuo Han, **angyang Ju, Benjamin Nachman in The European Physical Journal C (2023)

  4. No Access

    Article

    Road disease detection algorithm based on YOLOv5s-DSG

    Automatic detection and classification of road damages are critical for the timely maintenance and repair of road surfaces. To address issues in road damage detection, such as single detection type, low detect...

    Wanni **ang, Haichen Wang, Yuan Xu, Yixuan Zhao in Journal of Real-Time Image Processing (2023)

  5. Article

    Open Access

    Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaKPC-2 in a tertiary hospital in China

    The prevalence of multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKP) has gradually increased. It poses a severe threat to human health. However, polymyxin-resistant hvKP is rare. Here, we collected eight ...

    Mengli Tang, Jun Li, Zhaojun Liu, Fengjun **a, Changhang Min in BMC Microbiology (2023)

  6. No Access

    Article

    Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury

    The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis....

    David Van Wyck, Bradley J. Kolls, Haichen Wang in Experimental Brain Research (2022)

  7. No Access

    Article

    Mechanism of miR-378a-3p enriched in M2 macrophage-derived extracellular vesicles in cardiomyocyte pyroptosis after MI

    The development of novel therapies targeting cardiomyocyte pyroptosis is needed for myocardial infarction (MI). The current study sought to analyze the role and mechanism of M2 macrophage-derived extracellular...

    Wei Yuan, **ao Liang, Yingying Liu, Haichen Wang in Hypertension Research (2022)

  8. Article

    Open Access

    Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria

    The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure. However, polymyxin B-heteroresistant isolates are rare i...

    Jun Li, Mengli Tang, Fengjun **a, Changhang Min, Yongmei Hu in BMC Microbiology (2022)

  9. Article

    Open Access

    Distribution, characterization, and antibiotic resistance of hypervirulent Klebsiella pneumoniae isolates in a Chinese population with asymptomatic bacteriuria

    Asymptomatic bacteriuria (ASB) frequently occurs among all ages and may develop into urinary tract infections (UTIs). Hypervirulent Klebsiella pneumoniae (hvKP) has become a new threat to human health. In our stu...

    Jun Li, Yanbing Li, Mengli Tang, Fengjun **a, Changhang Min, Yongmei Hu in BMC Microbiology (2022)

  10. No Access

    Article

    Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage

    Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved pharmacological interventions that improve outcomes. Apolipoprotein E (apoE) has emerged as a pro...

    Haichen Wang, Timothy D. Faw, Yufeng Lin, Shan Huang in Neurocritical Care (2021)

  11. Article

    Open Access

    Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection

    The aim of this study was to analyze the role of blood biomarkers regarding preoperative inflammation and coagulation in predicting the postoperative in-hospital mortality of patients with type A acute aortic ...

    Ming Li, Suochun Xu, Yang Yan, Haichen Wang, Jianjie Zheng in Scientific Reports (2021)

  12. No Access

    Article

    Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice

    In recent years, the noble gas argon (Ar) has been extensively studied for its organ protection properties. While mounting in vitro and in vivo evidence indicates that argon provides neuroprotection in ischemi...

    Jennifer Creed, Viviana Cantillana-Riquelme, Bai Hui Yan, Shuang Ma in Neurocritical Care (2021)

  13. Article

    Open Access

    Characterization of fosfomycin resistance and molecular epidemiology among carbapenem-resistant Klebsiella pneumoniae strains from two tertiary hospitals in China

    Fosfomycin has been proven to be a vital choice to treat infection caused by multidrug resistance bacteria, especially carbapenem-resistant Klebsiella pneumoniae (CRKP). However, fosfomycin resistant cases has be...

    Haichen Wang, Changhang Min, Jun Li, Ting Yu, Yongmei Hu, Qingya Dou in BMC Microbiology (2021)

  14. Article

    Open Access

    Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

    Traumatic brain injury (TBI) is a global cause of morbidity and mortality. Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiograp...

    Zeyu Wang, Haichen Wang, Ryan Becker, Joseph Rufo in Microsystems & Nanoengineering (2021)

  15. Article

    Open Access

    Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

    Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages...

    Syed Faaiz Enam, Sajidur Rahman Kader, Nicholas Bodkin in Journal of Neuroinflammation (2020)

  16. Article

    Open Access

    Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Beilei Lei, Michael L. James, Ji Liu, Guanen Zhou in Scientific Reports (2020)

  17. Article

    Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury

    Over the last few decades, increasing evidence demonstrates that the neuroinflammatory response is a double-edged sword. Although overly robust inflammatory responses may exacerbate secondary tissue injury, in...

    Michael L. James, Jordan M. Komisarow, Haichen Wang in Neurotherapeutics (2020)

  18. No Access

    Article

    Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury

    In our recent study, we observed consistent increases in miR-124-3p levels in exosomes derived from cultured BV2 microglia which was treated with repetitive traumatic brain injury (rTBI) mouse model brain extr...

    Dai Li, Shan Huang, Zhenyu Yin, Jialin Zhu, **ntong Ge in Neurochemical Research (2019)

  19. Article

    Open Access

    Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model

    At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain infl...

    Daniel T. Laskowitz, Haichen Wang, Tony Chen, David T. Lubkin in Scientific Reports (2017)

  20. Article

    Open Access

    Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage

    Scientific Reports 6: Article number: 34834; published online: 07 October 2016; updated: 05 January 2017. The Competing Financial Interests statement in this Article should read: “D.T.L. is an officer of Aegis...

    Beilei Lei, Michael L. James, Ji Liu, Guanen Zhou in Scientific Reports (2017)

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