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Article
Open AccessOxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2
During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment. Howeve...
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Article
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated by complexes of 15-lipoxyge...
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Article
Open Access(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis
Drug-induced liver injury is the major cause of acute liver failure. However, the underlying mechanisms seem to be multifaceted and remain poorly understood, resulting in few effective therapies. Here, we repo...
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Article
Open AccessNovel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS
Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidi...
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Article
Open AccessIdentification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
Caffeine is a major component of xanthine alkaloids and commonly consumed in many popular beverages. Due to its occasional side effects, reduction of caffeine in a natural way is of great importance and econom...
