10 Result(s)
within
Hai** Shu
Biomedicine
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Article
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol.
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Article
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
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Article
Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats
Focal cerebral ischemia results in an increased expression of matrix metalloproteinase-9 (MMP-9), which induces vasogenic brain edema via disrupting the blood–brain barrier (BBB) integrity. Recent studies from...
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Article
Expression Patterns of TRPC1 in Cortical Lesions from Patients with Focal Cortical Dysplasia
Focal cortical dysplasia (FCD) is known as a common cause of chronic refractory epilepsy, but the underlying mechanisms of the factors that lead to FCD-related epilepsy are unclear. Previous studies have shown...
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Open AccessGenomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation
Li Yu, Ya-** Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkey Rhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high-alt...
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Open AccessThe histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling
A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the ...
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Article
Evaluation of the Impacts of Formulation Parameters on the Pharmacokinetics and Bioequivalence of Risperidone Orodispersible Film: a Physiologically Based Pharmacokinetic Modeling Approach
The purpose of this study was to investigate the impacts of the formulation parameters on the pharmacokinetics and bioequivalence of risperidone orodispersible film (ODF) using physiologically based pharmacoki...
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Article
Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling
The risk of drug-induced liver injury (DILI) poses a major challenge for development of natural products derived from traditional Chinese medicines (NP-TCMs). It is urgent to find a new method for the safety a...
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Article
Identifying Patients with Epilepsy Having Depression/Anxiety Disorder Using Common Spatial Patterns of Functional EEG Networks
The presentation of epilepsy with depression/anxiety disorder (E-AD) is a complex comorbidity, and a systematic psychiatric screen poses a heavy economic burden on the patients. Typically, distinguishing betwe...
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Article
Open AccessResearch progress on multiple cell death pathways of podocytes in diabetic kidney disease
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal failure. The injury and ...
