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Article
Open AccessA functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety
Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of micro...
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Article
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study ...
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Article
Open AccessModulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach
Representing a phylogenetically old and very basic mechanism of inhibitory neurotransmission, glycine receptors have been implicated in the modulation of behavioral components underlying defensive responding t...
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Article
Nutzer und Nutzung von Selbsthilfegruppen für pflegende Angehörige von Alzheimer-Patienten
Die Pflege von Patienten mit der Alzheimer-Krankheit (AK) geht mit einer erhöhten Belastung für die pflegenden Angehörigen (PA) einher. Während Therapieoptionen und niederschwellige Angebote zur Reduzierung de...
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Article
Peripartum changes in social support among women with and without anxiety and depressive disorders prior to pregnancy: a prospective-longitudinal study
This study aims to prospectively examine peripartum changes in social support in women with and without anxiety and depressive disorders prior to pregnancy. Data come from the Maternal Anxiety in Relation to I...
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Article
Das deutsche Forschungsnetz zu psychischen Erkrankungen
Psychische Störungen gehören zu den großen medizinischen und gesellschaftlichen Herausforderungen, treten in allen Lebensabschnitten auf und zählen zu den wichtigsten Volkskrankheiten. In Deutschland leiden je...
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Article
Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing
Corticotropin-releasing hormone (CRH) is a major regulator of the hypothalamic–pituitary–adrenal axis. Binding to its receptor CRHR1 triggers the downstream release of the stress response-regulating hormone co...
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Article
Peripartum changes in partnership quality among women with and without anxiety and depressive disorders prior to pregnancy: a prospective-longitudinal study
The purpose of this study is to prospectively examine peripartum changes in partnership characteristics among women with and without anxiety and depressive disorders prior to pregnancy. In the prospective-long...
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Article
Open AccessMAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy
Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of s...
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Article
Erratum zu: Psychische Störungen in der Allgemeinbevölkerung. Studie zur Gesundheit Erwachsener in Deutschland und ihr Zusatzmodul „Psychische Gesundheit“ (DEGS1-MH)
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Article
Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance
To examine the specific distribution of liver fat content, visceral and subcutaneous adiposity in normal glucose tolerance (NGT/NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose toleran...
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Article
Open AccessThe functional −1019C/G HTR1A polymorphism and mechanisms of fear
Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, a...
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Article
Psychische Störungen in der Allgemeinbevölkerung
Die „Studie zur Gesundheit Erwachsener in Deutschland“ (DEGS1) und ihr Zusatzmodul „Psychische Gesundheit“ (DEGS1-MH) erlauben erstmals seit dem 15 Jahre zurückliegenden Bundesgesundheitssurvey (BGS98) aktuell...
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Article
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy
Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoam...
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Article
Posttraumatische Belastungsstörungen nach Auslandseinsätzen deutscher Soldaten
Internationale Studien deuten auf ein ansteigendes Risiko für Posttraumatische Belastungsstörungen (PTBS) bei Soldaten mit zunehmender Dauer des Auslandseinsatzes hin. In der vorliegenden Arbeit soll der Frage...
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Article
Neuropeptide S receptor gene — converging evidence for a role in panic disorder
Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate ...
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Article
Demenz und Depression determinieren Pflegebedürftigkeit bei M. Parkinson
Die Parkinson-Krankheit (PK) ist häufig durch Demenz und Depression gekennzeichnet, die den Krankheitsverlauf erschweren und das Risiko einer Pflegebedürftigkeit zusätzlich erhöhen können. Über die genauen Zus...
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Article
Longitudinale Assoziationen zwischen depressiven Symptomen und Typ-2-Diabetes sowie deren Auswirkung auf die Mortalität von Hausarztpatienten
Es gibt widersprüchliche Befunde darüber, ob depressive Symptome Risikofaktoren für die Neumanifestation eines Diabetes sind oder ob umgekehrt auch Diabetes ein Risikofaktor für depressive Zustände ist. Daher ...
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Article
Open AccessAdverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population
GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be n...
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Reference Work Entry In depth
The Societal Costs of Anxiety and Mood Disorders: An Epidemiological Perspective
This chapter reviews the epidemiological literature on the prevalence and adverse societal consequences of anxiety and mood disorders. A special emphasis is put on the recently collected data from the complete...
