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Article
Open AccessA contemporary case series of Fournier’s gangrene at a Swiss tertiary care center—can scoring systems accurately predict mortality and morbidity?
Fournier’s gangrene (FG) is a life-threatening infection of the genital, perineal, and perianal regions with a morbidity range between 3 and 67%. Our aim is to report our experience in treatment of FG and to a...
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Article
Harnblasenkarzinomzelllinien als Modellsysteme zur Pathobiologie des Harnblasenkarzinoms
Tumorzelllinien stellen wertvolle präklinische Modelle sowohl zur Aufklärung tumorbiologischer Mechanismen als auch zur Identifizierung therapeutischer Zielstrukturen und Prüfung von pharmakologisch aktiven Wi...
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Article
Photoselektive Vaporisation der Prostata
Wir berichten über unsere Erfahrungen mit der photoselektiven Vaporisation der Prostata (PVP) bei Patienten mit symptomatischer benigner Prostatahyperplasie (BPH) und Prostataadenomen >80 cm3.
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Article
Open AccessCoordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
In prostate carcinoma (PCa) increased DNA methylation (‘hypermethylation’) occurs at specific genes such as GSTP1. Nevertheless, overall methylation can be decreased (‘hypomethylation’) because methylation of rep...
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Article
Open AccessE-cadherin involved in inactivation of WNT/β-catenin signalling in urothelial carcinoma and normal urothelial cells
Constitutive activation of WNT signalling through β-catenin, which leads to increased transcription of TCF/β-catenin target genes, is crucial in the development of many human tumour types including colorectal car...
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Article
Open AccessDestabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder
The most frequent genetic alteration in transitional cell carcinoma of the urinary bladder (TCC) is loss of chromosome 9 which targets CDKN2A on 9p. The targets on 9q are not confirmed. Here, 81 advanced TCC spec...
