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Chapter
T Cell Recognition of Superantigens
The specificity of the immune system is determined by antigen (Ag) receptors clonally expressed on T and B lymphocytes. These differ remarkably in their ligand specificity: While the Ag receptors of B lymphocy...
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Chapter and Conference Paper
Pgp-1 (Ly 24) As a Marker of Murine Memory T Lymphocytes
It is generally accepted that the primary immune response to an antigen involves the formation of long-lived, antigen-specific memory cells, in addition to effector cells. These memory cells are thought to be ...
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Chapter and Conference Paper
Clonal Deletion of Autoreactive T Lymphocytes: Insights from Neonatal Ontogeny
It is now well established that intrathymic clonal deletion of autoreactive cells is an important mechanism for maintaining tolerance to self antigens (Kappler et al. 1987, 1988; MacDonald et al. 1988b). Howev...
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Chapter and Conference Paper
Activation Requirements for Resting T Lymphocytes
The growth of T lymphocytes is generally believed to be under dual control (reviewed in Smith 1980). Initially, interaction of specific antigen receptors on the T-cell surface with antigen (or its presumed ope...