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  1. No Access

    Chapter

    Development and Selection of Vα14i NKT Cells

    H. R. MacDonald, M. P. Mycko in T Cell Activation by CD1 and Lipid Antigens (2007)

  2. No Access

    Article

    The tumor suppressor p16Ink4a regulates T lymphocyte survival

    In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a sp...

    T Bianchi, N Rufer, H R MacDonald, M Migliaccio in Oncogene (2006)

  3. No Access

    Chapter

    T Cell Recognition of Superantigens

    The specificity of the immune system is determined by antigen (Ag) receptors clonally expressed on T and B lymphocytes. These differ remarkably in their ligand specificity: While the Ag receptors of B lymphocy...

    T. Herrmann, H. R. MacDonald in Superantigens (1991)

  4. No Access

    Chapter and Conference Paper

    Pgp-1 (Ly 24) As a Marker of Murine Memory T Lymphocytes

    It is generally accepted that the primary immune response to an antigen involves the formation of long-lived, antigen-specific memory cells, in addition to effector cells. These memory cells are thought to be ...

    H. R. MacDonald, R. C. Budd, J.-C. Cerottini in Immunological Memory (1990)

  5. No Access

    Chapter and Conference Paper

    Clonal Deletion of Autoreactive T Lymphocytes: Insights from Neonatal Ontogeny

    It is now well established that intrathymic clonal deletion of autoreactive cells is an important mechanism for maintaining tolerance to self antigens (Kappler et al. 1987, 1988; MacDonald et al. 1988b). Howev...

    H. R. MacDonald, R. K. Lees, J. A. Louis in Progress in Immunology (1989)

  6. No Access

    Chapter and Conference Paper

    Activation Requirements for Resting T Lymphocytes

    The growth of T lymphocytes is generally believed to be under dual control (reviewed in Smith 1980). Initially, interaction of specific antigen receptors on the T-cell surface with antigen (or its presumed ope...

    H. R. MacDonald, F. Erard in Specificity and Function of Clonally Develo** T Cells (1986)

  7. No Access

    Chapter

    Non Antigen-Specific Surface Molecules Involved in T Lymphocyte Function

    Until recently, it was generally assumed that cell surface structures other than antigen-specific receptors were not involved in T cell function. However, the reports in 1979 by Nakayama et al.1 and Shinohara ...

    J.-C. Cerottini, H. R. MacDonald, J. Lowenthal, R. Shimonkevitz in Immune Regulation (1985)

  8. No Access

    Chapter

    Heterogeneity of Inhibition of Cytolytic T Lymphocyte Clones by Monoclonal Anti-Lyt-2/3 Antibodies: Parallel Effects on Cytolysis, Proliferation and Lymphokine Secretion

    The interaction between cytolytic T lymphocytes (CTL) and target cells is presumed to be mediated by antigen-specific receptors on the surface of CTL. One approach to the identification and characterization of...

    H. R. MacDonald, A. L. Glasebrook, O. Acuto… in Mechanisms of Cell-Mediated Cytotoxicity (1982)

  9. No Access

    Article

    Antibody-dependent cellular cytotoxicity in cancer patients: lack of prognostic value

    Antibody-dependent cellular cytotoxicity (“killer” (K) cell activity) of peripheral-blood lymphomononuclear (LMN) cells was determined in patients with early and advanced cancer, and the results compared with ...

    J A McCredie, H R MacDonald in British Journal of Cancer (1980)

  10. No Access

    Chapter

    Separation of Earthworm Coelomocytes by Velocity Sedimentation

    Earthworm leukocytes (coelomocytes) are heterogeneous morphologically (1,2) and participate in diverse functions including graft rejection (3), phagocytosis (1), formation of rosettes with SRBC (4), and mitoge...

    E. L. Cooper, H. R. MacDonald, B. Sordat in Function and Structure of the Immune System (1979)

  11. Article

    Antibody-dependent Cell-mediated Destruction of Human Erythrocytes Sensitized in ABO and Rhesus Fetal-Maternal Incompatibilities

    Extract: Antibody-dependent cell-mediated cytotoxicity (ADCMC) was measured in a 51Cr-release assay with antibody-sensitized human red blood cells (RBC) as target cells and nonimmune isologous or autologous monon...

    S A Zawodnik, G D Bonnard, E Gautier, H R Macdonald in Pediatric Research (1976)

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