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  1. No Access

    Chapter

    T Cell Recognition of Superantigens

    The specificity of the immune system is determined by antigen (Ag) receptors clonally expressed on T and B lymphocytes. These differ remarkably in their ligand specificity: While the Ag receptors of B lymphocy...

    T. Herrmann, H. R. MacDonald in Superantigens (1991)

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    Chapter and Conference Paper

    Pgp-1 (Ly 24) As a Marker of Murine Memory T Lymphocytes

    It is generally accepted that the primary immune response to an antigen involves the formation of long-lived, antigen-specific memory cells, in addition to effector cells. These memory cells are thought to be ...

    H. R. MacDonald, R. C. Budd, J.-C. Cerottini in Immunological Memory (1990)

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    Chapter and Conference Paper

    Clonal Deletion of Autoreactive T Lymphocytes: Insights from Neonatal Ontogeny

    It is now well established that intrathymic clonal deletion of autoreactive cells is an important mechanism for maintaining tolerance to self antigens (Kappler et al. 1987, 1988; MacDonald et al. 1988b). Howev...

    H. R. MacDonald, R. K. Lees, J. A. Louis in Progress in Immunology (1989)

  4. No Access

    Chapter and Conference Paper

    Activation Requirements for Resting T Lymphocytes

    The growth of T lymphocytes is generally believed to be under dual control (reviewed in Smith 1980). Initially, interaction of specific antigen receptors on the T-cell surface with antigen (or its presumed ope...

    H. R. MacDonald, F. Erard in Specificity and Function of Clonally Develo** T Cells (1986)