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Fluorescence Techniques for Studying Ion Channel Gating: VCF, FRET, and LRET

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  1. Article

    Open Access

    A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

    Voltage-gated KCNQ1 channels contain four separate voltage-sensing domains (VSDs) and a pore domain (PD). KCNQ1 expressed alone opens when the VSDs are in an intermediate state. In cardiomyocytes, KCNQ1 co-exp...

    **aoan Wu, Marta E. Perez, Sergei Yu Noskov, H. Peter Larsson in Communications Biology (2021)

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  2. Article

    Open Access

    Gating mechanism of hyperpolarization-activated HCN pacemaker channels

    Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN cha...

    Rosamary Ramentol, Marta E. Perez, H. Peter Larsson in Nature Communications (2020)

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  3. Article

    Open Access

    Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations

    KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate IKs, the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential...

    Gary Peng, Rene Barro-Soria, Kevin J. Sampson, H. Peter Larsson… in Scientific Reports (2017)

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