Skip to main content

8 Result(s)

within H. Peter Larsson Remove this filter

and

  1. Article

    Open Access

    A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

    Voltage-gated KCNQ1 channels contain four separate voltage-sensing domains (VSDs) and a pore domain (PD). KCNQ1 expressed alone opens when the VSDs are in an intermediate state. In cardiomyocytes, KCNQ1 co-exp...

    **aoan Wu, Marta E. Perez, Sergei Yu Noskov, H. Peter Larsson in Communications Biology (2021)

    Download PDF (1777 KB) View Article

  2. Article

    Open Access

    Gating mechanism of hyperpolarization-activated HCN pacemaker channels

    Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN cha...

    Rosamary Ramentol, Marta E. Perez, H. Peter Larsson in Nature Communications (2020)

    Download PDF (2671 KB) View Article

  3. No Access

    Living Reference Work Entry In depth

    Fluorescence Techniques for Studying Ion Channel Gating: VCF, FRET, and LRET

    Ehud Y. Isacoff, H. Peter Larsson in Encyclopedia of Biophysics

  4. Article

    Open Access

    Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations

    KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate IKs, the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential...

    Gary Peng, Rene Barro-Soria, Kevin J. Sampson, H. Peter Larsson… in Scientific Reports (2017)

    Download PDF (6172 KB) View Article

  5. No Access

    Article

    KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

    The functional properties of KCNQ1 channels are highly dependent on associated KCNE-β subunits. Mutations in KCNQ1 or KCNE subunits can cause congenital channelopathies, such as deafness, cardiac arrhythmias a...

    Rene Barro-Soria, Santiago Rebolledo, Sara I. Liin, Marta E. Perez… in Nature Communications (2014)

  6. No Access

    Article

    Strong cooperativity between subunits in voltage-gated proton channels

    The voltage-gated proton channel Hv1 forms a dimer, but each monomer contains a voltage sensor domain that forms a pore for proton conduction. Now functional work with Ciona intestinalis Hv protein reveals that t...

    Carlos Gonzalez, Hans P Koch, Ben M Drum… in Nature Structural & Molecular Biology (2010)

  7. No Access

    Article

    Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages

    Hyperpolarization-activated cyclic-nucleotide-gated (HCN) ion channels are found in rhythmically firing cells in the brain and in the heart1, where the cation current through HCN channels (called Ih or If) causes...

    Roope Männikkö, Fredrik Elinder, H. Peter Larsson in Nature (2002)

  8. No Access

    Article

    Ionic channels in the plasma membrane ofSchizosaccharomyces pombe: Evidence from patch-clamp measurements

    Patch-clamp studies of the yeastSchizosaccharomyces pombe reveal that the plasma membrane contains a voltage-gated channel mildly selective for potassium over sodium, lithium, and chloride. The channel exhibits s...

    Vladimír Vacata, Milan Höfer, H. Peter Larsson… in Journal of Bioenergetics and Biomembranes (1993)