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  1. Article

    Open Access

    Gating mechanism of hyperpolarization-activated HCN pacemaker channels

    Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN cha...

    Rosamary Ramentol, Marta E. Perez, H. Peter Larsson in Nature Communications (2020)

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  2. Article

    Open Access

    Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations

    KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate IKs, the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential...

    Gary Peng, Rene Barro-Soria, Kevin J. Sampson, H. Peter Larsson… in Scientific Reports (2017)

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  3. No Access

    Article

    KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

    The functional properties of KCNQ1 channels are highly dependent on associated KCNE-β subunits. Mutations in KCNQ1 or KCNE subunits can cause congenital channelopathies, such as deafness, cardiac arrhythmias a...

    Rene Barro-Soria, Santiago Rebolledo, Sara I. Liin, Marta E. Perez… in Nature Communications (2014)

  4. No Access

    Article

    Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages

    Hyperpolarization-activated cyclic-nucleotide-gated (HCN) ion channels are found in rhythmically firing cells in the brain and in the heart1, where the cation current through HCN channels (called Ih or If) causes...

    Roope Männikkö, Fredrik Elinder, H. Peter Larsson in Nature (2002)