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Article
Open AccessGating mechanism of hyperpolarization-activated HCN pacemaker channels
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN cha...
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Article
Open AccessGating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations
KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate IKs, the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential...
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Article
KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
The functional properties of KCNQ1 channels are highly dependent on associated KCNE-β subunits. Mutations in KCNQ1 or KCNE subunits can cause congenital channelopathies, such as deafness, cardiac arrhythmias a...
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Article
Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages
Hyperpolarization-activated cyclic-nucleotide-gated (HCN) ion channels are found in rhythmically firing cells in the brain and in the heart1, where the cation current through HCN channels (called Ih or If) causes...