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  1. Article

    Open Access

    Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)

    The presence of mesorectal fascia (MRF) invasion, grade 4 extramural venous invasion (EMVI), tumour deposits (TD) or extensive or bilateral extramesorectal (lateral) lymph nodes (LLN) on MRI has been suggested...

    K. van den Berg, D. P. Schaap, E. L. K. Voogt, T. E. Buffart… in BMC Cancer (2022)

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  2. Article

    Open Access

    Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib

    Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...

    R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen… in BMC Cancer (2019)

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