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Article
Damage Evolution in Dry and Saturated Brittle Sandstone Revealed by Acoustic Characterization Under Uniaxial Compression
We present results of P-wave velocities and acoustic emission (AE) activities of a calcareous sandstone, collected from the Three Gorges Reservoir (TGR) area, under uniaxial loading to investigate the stress-i...
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Article
Identification and Mitigation of Error in the Terzaghi Bias Correction for Inhomogeneous Material Discontinuities
Use of the scanline map** technique in geometric surveys of rock discontinuities can often lead to a bias, in that discontinuities are not always observed when they are at small angles to the scanline. Terza...
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Article
Open AccessAn epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers
Epithelial–mesenchymal transition (EMT), a crucial mechanism in development, mediates aggressiveness during carcinoma progression and therapeutic refractoriness. The reversibility of EMT makes it an attractive...
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Article
Study on the support–anchor combined technique to control perilous rock at the source of avalanche by fracture mechanics
As a kind of existing and potential geological disaster at the source of avalanche on cliffs or steep slopes, perilous rock has developed in the western area of China widely, and it has posed a serious threat ...
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Article
Open AccessUbiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery
Our recent study observed that the expression of ubiquitin D (UBD), a member of ubiquitin-like modifier family, was upregulated in colon cancer parenchymal cells. The present study further investigated the cli...
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Article
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a do...
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Article
Open AccessReversibility of apoptosis in cancer cells
Apoptosis is a cell suicide programme characterised by unique cellular events such as mitochondrial fragmentation and dysfunction, nuclear condensation, cytoplasmic shrinkage and activation of apoptotic protea...