Early Brain Injury or Cerebral Vasospasm
Volume 1: Pathophysiology
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Article
Open AccessThe development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H
The application of patient-derived (PD) in vitro tumor models represents the classical strategy for clinical translational oncology research. Using these cellular heterogeneous cultures for the isolation of ca...
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Article
Open AccessDNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development
Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptio...
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Article
Open AccessCBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells
Glioblastoma is the most common and most lethal primary brain cancer. CBF1 (also known as Recombination signal Binding Protein for immunoglobulin kappa J, RBPJ) is the cardinal transcriptional regulator of the...
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Article
Giant cell tumor of the lumbar spine with intraperitoneal growth: case report and review of literature
Giant cell tumors of the spine are uncommon. Usually they are benign and solitary, but locally very aggressive. Most of them occur at the sacral spine. There are only 26 reported cases in the literature involv...
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Article
The impact of improved treatment strategies on overall survival in glioblastoma patients
The introduction of ALA-Fluorescence-guided surgery (FGS) followed by concomitant radiochemotherapy according to the Stupp-protocol is representative of the major changes in glioblastoma therapy in the past ye...
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Article
The impact of brain shift in deep brain stimulation surgery: observation and obviation
The impact of brain shift on deep brain stimulation surgery is considerable. In DBS surgery, brain shift is mainly caused by CSF loss. CSF loss can be estimated by post-surgical intracranial air. Different app...
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Article
A comparative study of perfusion CT and 99mTc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion
Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a pre...
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Article
Open AccessHeat-shock protein 70-dependent dendritic cell activation by 5-aminolevulinic acid-mediated photodynamic treatment of human glioblastoma spheroids in vitro
T-cell responses contribute to the anti-tumoural effect of photodynamic therapy (PDT). For such responses to occur, dendritic cells (DCs) have to migrate to the tumour, take up tumour antigens and respond to d...
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Book and Conference Proceedings
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Book and Conference Proceedings
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Article
Diagnostik und Therapie der spinalen vaskulären Malformationen
Gefäßmalformationen des Spinalkanals treten mit einer Inzidenz von über 5 bis 10 Fällen/Jahr/1 Mio. Einwohner auf. Zu ihnen gehören die spinalen arteriovenösen Malformationen (sAVM), die spinalen duralen arter...
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Chapter and Conference Paper
Visualization of Basic Flow Pattern in a Subarachnoid Hemorrhage Model with PIV-Measurement System
Despite current treatment strategies cerebral arterial spasm still constitutes the dominant secondary complication following aneurysmal subarachnoid hemorrhage (SAH) and continues to be associated with high mo...
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Book and Conference Proceedings
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Article
Spontaneous intracerebral haemorrhage in adults: a literature overview
Background. A large number of reports have analysed epidemiology, pathogenesis, symptomatology, diagnostics and options for medical and surgical treatment of intracerebral haemorrhage. Nevertheless, management st...
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Book and Conference Proceedings
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Book and Conference Proceedings
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Book and Conference Proceedings
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Chapter and Conference Paper
The effect of an intracisternal nimodipine slow-release system on cerebral vasospasm after experimental subarachnoid haemorrhage in the rat
Intracisternal slow delivery systems are a promising concept of local treatment of cerebral vasospasm after subarachnoid haemorrhage (SAH). The purpose of the actual study was to investigate for the first time...
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Chapter and Conference Paper
Simultaneous head rotation and lumboventricular lavage in patients after severe subarachnoid haemorrhage: an initial analysis of the influence on clot clearance rate and cerebral vasospasm
Some recent publications from Japan suggested that headshaking might attenuate cerebral vasospasm after subarachnoid haemorrhage (SAH) due to facilitated wash-out. It can also be assumed that the accepted bene...
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Chapter and Conference Paper
Results of direct and indirect revascularisation for adult European patients with Moyamoya angiopathy
There is little information concerning clinical data and revascularization procedures in adult European patients with Moyamoya disease. More data are available on juvenile European Moyamoya angiopathy and its ...
