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Article
Primary malignant rhabdoid tumours of the central nervous system: An immunohistochemical and ultrastructural study
Three cases of primary rhabdoid tumour of the CNS (RT-CNS) are presented. In case 1 a hemispheric tumour developed in a 10.5 months old girl, who survived for 6 months after incomplete resection, radio- and po...
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Article
Randomized comparison of rotational chemotherapy in high-risk acute lymphoblastic leukaemia of childhood — follow up after 9 years
A frequent change of drug combinations may circumvent drug resistance in the treatment of patients with acute lymphoblastic leukaemia (ALL). In study COALL 85/89 201 children with high-risk ALL were randomized...
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Article
Abstracts
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Article
Wilms' tumor — treatment and prognosis of 373 children
Between June 1980 and June 1988, 373 patients with Wilms' tumors were diagnosed and treated (34.5%, stage I; 34.5%, stage II; 14.8%, stage III; 10.7%, stage IV; and 5.4%, stage V). In all, 11% of the patients ...
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Chapter and Conference Paper
Phase I/II Trial with Low-Dose Interleukin-2 and Interferon-Gamma in Children with High-Risk Leukemia and Non-Hodgkin’s Lymphoma After Autologous Bone Marrow Transplantation
About 40% of patients suffering from early (first remission duration under 18 months) or recurrent relapses of acute lymphoblastic leukemia (ALL) remain relapse-free after being treated with allogeneic bone ma...
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Chapter and Conference Paper
Bone Marrow Blast Count at Day 28 as the Single Most Important Prognostic Factor in Childhood Acute Lymphoblastic Leukemia
Intensification of therapy and risk-adapted treatment have increased the cure rates for childhood acute lymphocytic leukemia (ALL) to 60%–70% [1–5]. Among the prognostic parameters the initial white blood coun...
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Chapter and Conference Paper
Improved Prognosis for Childhood Acute Lymphocytic Leukemia with Very High White Blood Cell Count (> 100/nl) with Rotation of Non-Cross-Resistant Drug Combinations
Among several initial prognostic factors in acute lymphoblastic leukemia (ALL), i.e., age, hepatosplenomegaly, immunologic subtype, and chromosomal abnormalities [1–4], an elevated white blood count (WBC) at d...
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Article
Combination chemotherapy in malignant non-seminomatous germ-cell tumors: results of a cooperative study of the German Society of Pediatric Oncology (MAKEI 83)
In January 1983, the German Society of Pediatric Oncology started a cooperative trial (MAKEI 83) for non-testicular germ-cell tumors. The pilot phase closed in December 1985. The treatment regimen was stratifi...
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Chapter and Conference Paper
New Aspects in the Treatment of Childhood Rhabdomyosarcoma: Results of the German Cooperative Soft-Tissue Sarcoma Study (CWS-81)
Prior to the introduction of chemotherapy only 10–20% of children suffering from rhabdomyosarcomas (RMS) were successfully treated by surgery alone [1–4]. The introduction of combined multi-agent cytostatic th...
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Chapter and Conference Paper
Aggressive Combination Chemotherapy of Bone Marrow Relapse in Childhood Acute Lymphoblastic Leukemia Containing Aclacinomycin-A: A Multicentric Trial
An intensive 7-day combination chemotherapy protocol was designed to reinduce children with early bone marrow relapse of acute lymphoblastic leukemia (less than 6 months after the end of or during preceding tr...
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Article
Intermediate-dose methotrexate in the treatment of childhood acute lymphocytic leukaemia: lack of benefit during maintenance therapy following intensive induction therapy
One hundred and fifty-one children with acute lymphocytic leukaemia (ALL) received multiple agent induction chemotherapy followed by intensive phase treatment. One hundred and thirty-seven patients were random...