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  1. No Access

    Article

    Advances in Cellular Models to Explore the Pathophysiology of Amyotrophic Lateral Sclerosis

    Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is fatal for most patients less than 3 years from when the first symptoms appear. The aetiologies for sporadic and most f...

    C. Veyrat-Durebex, P. Corcia, A. Dangoumau, F. Laumonnier… in Molecular Neurobiology (2014)

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    Article

    Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration

    Amyotrophic lateral sclerosis (ALS) is a disease caused by the degeneration of motor neurons (MNs) leading to progressive muscle weakness and atrophy. Several molecular pathways have been implicated, such as g...

    C. Maurel, A. Dangoumau, S. Marouillat, C. Brulard, A. Chami… in Molecular Neurobiology (2018)

  3. Article

    Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model

    In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic dysfunction and neuro-inflammation. The fibroblast growth factor 21 (FGF21) plays an important ro...

    J. B. Delaye, D. Lanznaster, C. Veyrat-Durebex, A. Fontaine, G. Bacle… in Neurotherapeutics (2021)

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