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  1. No Access

    Article

    Rates of psychiatric disorders in a clinical study group of adolescents with extreme obesity and in obese adolescents ascertained via a population based study

    OBJECTIVE: To compare rates of DSM-IV psychiatric disorders between (1) a clinical study group of extremely obese adolescents and young adults, (2) gender-matched population-based obese controls and (3) a popu...

    B Britz, W Siegfried, A Ziegler, C Lamertz… in International Journal of Obesity (2000)

  2. No Access

    Article

    Recognition and management of overweight and obesity in primary care in Germany

    BACKGROUND: In contrast to the well-documented high prevalence of overweight and obesity in the general population, the prevalence, recognition rates and management by primary care physicians—as the core gatekeep...

    P Bramlage, H-U Wittchen, D Pittrow, W Kirch, P Krause… in International Journal of Obesity (2004)

  3. No Access

    Reference Work Entry In depth

    The Societal Costs of Anxiety and Mood Disorders: An Epidemiological Perspective

    This chapter reviews the epidemiological literature on the prevalence and adverse societal consequences of anxiety and mood disorders. A special emphasis is put on the recently collected data from the complete...

    R. C. Kessler, P. S. Wang, H.-U. Wittchen in Handbook of Disease Burdens and Quality of… (2010)

  4. No Access

    Article

    Neuropeptide S receptor gene — converging evidence for a role in panic disorder

    Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate ...

    K Domschke, A Reif, H Weber, J Richter, C Hohoff, P Ohrmann… in Molecular Psychiatry (2011)

  5. No Access

    Article

    MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy

    Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoam...

    A Reif, J Richter, B Straube, M Höfler, U Lueken, A T Gloster… in Molecular Psychiatry (2014)

  6. Article

    Open Access

    The functional −1019C/G HTR1A polymorphism and mechanisms of fear

    Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, a...

    B Straube, A Reif, J Richter, U Lueken, H Weber, V Arolt… in Translational Psychiatry (2014)

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  7. No Access

    Article

    Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance

    To examine the specific distribution of liver fat content, visceral and subcutaneous adiposity in normal glucose tolerance (NGT/NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose toleran...

    A-L Borel, J-A Nazare, J Smith, P Aschner, P Barter… in International Journal of Obesity (2015)

  8. Article

    Open Access

    MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy

    Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of s...

    C Ziegler, J Richter, M Mahr, A Gajewska, M A Schiele… in Translational Psychiatry (2016)

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  9. No Access

    Article

    Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing

    Corticotropin-releasing hormone (CRH) is a major regulator of the hypothalamic–pituitary–adrenal axis. Binding to its receptor CRHR1 triggers the downstream release of the stress response-regulating hormone co...

    H Weber, J Richter, B Straube, U Lueken, K Domschke, C Schartner… in Molecular Psychiatry (2016)

  10. Article

    Open Access

    Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach

    Representing a phylogenetically old and very basic mechanism of inhibitory neurotransmission, glycine receptors have been implicated in the modulation of behavioral components underlying defensive responding t...

    U Lueken, M Kuhn, Y Yang, B Straube, T Kircher, H-U Wittchen… in Translational Psychiatry (2017)

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  11. No Access

    Article

    GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

    The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study ...

    J Deckert, H Weber, C Villmann, T B Lonsdorf, J Richter… in Molecular Psychiatry (2017)

  12. Article

    Open Access

    A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

    Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of micro...

    L. G. Hommers, J. Richter, Y. Yang, A. Raab, C. Baumann… in Translational Psychiatry (2018)

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