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  1. Article

    Open Access

    Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

    Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species (ROS) to protect cancer cell from oxidative damage. ...

    H-Q Ju, Y-X Lu, Q-N Wu, J Liu, Z-L Zeng, H-Y Mo, Y Chen, T Tian, Y Wang… in Oncogene (2017)

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  2. No Access

    Article

    ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

    Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis. Metaboli...

    H-Q Ju, G Zhan, A Huang, Y Sun, S Wen, J Yang, W-h Lu, R-h Xu, J Li, Y Li… in Leukemia (2017)

  3. Article

    Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

    Side population (SP) cells within tumors are a small fraction of cancer cells with stem-like properties that can be identified by flow cytometry analysis based on their high ability to export certain compounds...

    P-P Liu, J Liao, Z-J Tang, W-J Wu, J Yang, Z-L Zeng, Y Hu… in Cell Death & Differentiation (2014)

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