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Article
Erratum: Map** the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Correction to: Leukemia (2015) 29, 647–659; doi:10.1038/leu.2014.233; published online 29 August 2014 Following the publication of this article, the authors noted that there were errors in Figure 4a and c. The...
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Article
Open AccessCarfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini
Recent studies suggest that multiple myeloma is an immunogenic disease, which might be effectively targeted by antigen-specific T-cell immunotherapy. As standard of care in myeloma includes proteasome inhibito...
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Article
Map** the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen (HLA) ligands, termed the HLA ligandome. In this ...
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Article
Tumorvakzinierung
Die aktive Immunisierung gegen maligne Erkrankungen hat in den letzten Jahren bahnbrechende Erfolge verzeichnet. Immer mehr definierte Zielantigene finden Einzug in klinische Studien, und mit Ipilimumab und Si...
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Article
Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia
The therapeutic efficacy of humanized or chimeric second-generation antitumor antibodies is clearly established, but often limited. In recent years, defined modifications of the glycosylation pattern or the am...
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Article
Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity
There is evidence from mouse models and humans that alterations in insulin action in the brain are accompanied by an obese phenotype; however, the impact of insulin with regard to behavioural aspects such as l...
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Article
Erratum: Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent
Correction to: Gene Therapy (2007) 14, 1175–1180; doi:10.1038/sj.gt.3302964 Since the above publication the authors have noticed that they unfortunately missed a grant support. The work was also supported by S...
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Article
A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells
We have previously reported that r28M, a recombinant bispecific single-chain antibody directed to a melanoma-associated proteoglycan (NG2) and the costimulatory CD28 molecule on T cells, induced T-cell activat...
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Chapter and Conference Paper
Impact of the IDO2 blocker D-1-methyltryptophan on the IDO activity of human tumors and dendritic cells
Clinical phase-I-trials with cancer patients have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-...
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Article
Identification of NM23-H2 as a tumour-associated antigen in chronic myeloid leukaemia
Therapeutic effects of haematopoietic stem cell transplantation are not limited to maximal chemoradiotherapy and subsequent bone marrow regeneration, but include specific as well as unspecific immune reactions...
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Article
Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent
The development of new treatments in the post-genomic era requires methods for safe delivery of foreign genetic information in vivo. As a transient, natural and controllable alternative to recombinant viruses or ...
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Article
Human peripheral blood monuclear cells transfected with messenger RNA stimulate antigen-specific cytotoxic T-lymphocytes in vitro
The efficiency of test vaccines needs to be evaluated by quantification of the triggered cellular immune response. Usually, for these assays, autologous target cells expressing the vaccine antigen are required...
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Article
Modeling the MHC class I pathway by combining predictions of proteasomal cleavage,TAP transport and MHC class I binding
Epitopes presented by major histocompatibility complex (MHC) class I molecules are selected by a multi-step process. Here we present the first computational prediction of this process based on in vitro experim...
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Article
Legionella pneumophila down-regulates MHC class I expression of human monocytic host cells and thereby inhibits T cell activation
Legionella (L.) pneumophila, the causative agent of Legionnaires’ disease, is an intracellular pathogen of alveolar macrophages that resides in a compartment displaying features of endoplasmatic reticulum (ER). ...
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Article
Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire
Human cytomegalovirus (HCMV) infection or reactivation is a cause of morbidity and mortality in immunocompromised individuals. In immunocompetent individuals, in contrast, HCMV is successfully controlled by sp...
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Article
Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
In the context of develo** a safe genetic vaccination strategy we tested and studied globin-stabilized mRNA-based vaccination in mice. This vaccination strategy has the advantages of genetic vaccination (ea...
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Article
Open AccessThe Tübingen approach: identification, selection and validation of tumor-associated HLA peptides for cancer therapy
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Article
CD4+ T cell-mediated immunity against prion proteins
The prion protein (PrPC) is essential for susceptibility to transmissible spongiform encephalopathies. A specific conformer of this protein (PrPSc) is, according to the 'protein only' hypothesis, the principal o...
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Article
High frequency of human cytomegalovirus (HCMV)-specific CD8+-T cells detected in a healthy CMV-seropositive donor
Human cytomegalovirus (HCMV) persists after infection but is controlled by cellular immune responses, particularly by CD8+ T cells. If infected individuals are immunosuppressed, HCMV can be reactivated. Upon tes...
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Article
Stimulation of TNFα expression by hyperosmotic stress
Hyperosmotic stress is known to induce apoptotic cell death, an effect previously attributed to seemingly ligand-independent clustering of tumour necrosis factor α (TNFα) receptors. An alternative explanation...
