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Article
Open AccessPerson-centered care content in medicine, occupational therapy, nursing, and physiotherapy education programs
Although person-centered care (PCC) ensures high-quality care for patients, studies have shown that it is unevenly applied in clinical practice. The extent to which future health care providers are currently o...
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Article
Open AccessIncreased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance
In this study, we show that during normal rat pregnancy, there is a gestational stage-dependent decrease in androgen receptor (AR) abundance in the gravid uterus and that this is correlated with the differenti...
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Article
Open AccessMolecular characterization of insulin resistance and glycolytic metabolism in the rat uterus
Peripheral insulin resistance and hyperandrogenism are the primary features of polycystic ovary syndrome (PCOS). However, how insulin resistance and hyperandrogenism affect uterine function and contribute to t...
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Article
Open AccessProgesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube
The fallopian tube transports the gametes to the fertilization site and delivers the embryo to the uterus at the optimal time for implantation. Progesterone and the classical progesterone receptor are involved...
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Article
Open AccessDirect effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...
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Article
Open AccessEndometrial progesterone resistance and PCOS
Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasi...
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Article
Open AccessThe classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone
The transport of gametes as well as the zygote is facilitated by motile cilia lining the inside of the fallopian tube. Progesterone reduces the ciliary beat frequency within 30 minutes in both cows and mice. T...
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Article
Open AccessComparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy
Several peripheral proteins that might be useful for detecting the presence of ectopic pregnancy (EP) have been evaluated, but none have been proven entirely useful in the clinic. We investigated the presence ...
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Article
Open AccessRapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube
The physiological regulation of ciliary beat frequency (CBF) within the fallopian tube is important for controlling the transport of gametes and the fertilized ovum. Progesterone influences gamete transport in...
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Article
Open AccessDistribution and hormonal regulation of membrane progesterone receptors β and γ in ciliated epithelial cells of mouse and human fallopian tubes
The controlled beating of cilia of the fallopian tube plays an important role in facilitating the meeting of gametes and subsequently transporting the fertilized egg to its implantation site. Rapid effects of ...
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Article
The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy
Decreased estrogen production is associated with changes in the skeletal, cardiovascular and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in force production occurs at...
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Chapter
Clinical Ramifications of Apoptosis in the Human Testis
In mammals, multiplication of germ cells in the testis is always accompanied by degeneration of some of the proliferating cells. During spermatogenesis, germ cell death occurs spontaneously at various phases o...
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Article
Apoptotic Cell Death in the Normal and Cryptorchid Human Testis: The Effect of Human Chorionic Gonadotropin on Testicular Cell Survival
Cryptorchidism is associated with histologic changes in the human testis apparent by 2 y of age. The mechanism accounting for these changes is still unknown. To clarify whether apoptosis plays a role in human ...
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Chapter
Role of Cumulus Cells in Oocyte Maturation
Resumption of meiosis (oocyte maturation) is normally triggered by the preovulatory LH surge, and the first meiotic division is completed at the time of follicle rupture. The mature follicle has receptors for ...
