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Article
Open AccessDevelopment of a bioassay to detect T-cell-activating impurities for T-cell-dependent bispecific antibodies
T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit a patient’s T cells to kill cancer cells. There are increasing numbers of TBDs in clinical trials, demonstrating ...
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Article
Global structure and seasonal variations of the migrating 6-h tide observed by SABER/TIMED
Ten years of SABER/TIMED temperature data are used to analyze the global structure and seasonal variations of the migrating 6-h tide from the stratosphere to the lower thermosphere. The amplitudes of the migra...
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Article
Characteristics and mechanisms of the annual asymmetry of thermospheric mass density
In this paper, globally-averaged, thermospheric total mass density, derived from the orbits of ∼5000 objects at 250, 400, and 550 km that were tracked from 1967 to 2006, has been used to quantitatively study t...
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Article
Open AccessSpontaneous generation of germline characteristics in mouse fibrosarcoma cells
Germline/embryonic-specific genes have been found to be activated in somatic tumors. In this study, we further showed that cells functioning as germline could be present in mouse fibrosarcoma cells (L929 cell ...
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Article
A comparison of mesospheric winds measured by FPI and meteor radar located at 40N
In this paper, winds derived from OH Meinel 892.0 nm detection by an FPI (Fabry-Perot Interferometer) are compared with the simultaneous wind measurements from a meteor radar during April–May of 2010. The peak...
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Article
Open AccessObservations of the first meteorological rocket of the Meridian Space Weather Monitoring Project
On June 3, 2010, the first meteorological rocket of the Meridian Space Weather Monitoring Project was successfully launched at the Hainan rocket launch site (19.5°N), China. This paper analyzes the vertical pr...
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Article
First observation of mesospheric and thermospheric winds by a Fabry-Perot interferometer in China
A Fabry-Perot interferometer, funded by the Meridian Project in China, was deployed at the **nglong station (40.2°N,117.4°E) of the National Astronomical Observatories in Hebei Province, China. The instrument ...
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Article
The first observation of the atmospheric tides in the mesosphere and lower thermosphere over Hainan, China
Fuke (19.5°N, 109.1°E) meteor radar is the first radar of the low latitudes of China, which is used to detect the wind in the mesosphere and lower thermosphere. In this paper, by using the wind data near three...
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Article
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
Talins link integrins to the actin cytoskeleton and are important for cell spreading. Sheetz and colleagues show that talin is dispensable for initial cell spreading but it is required for sustained cell sprea...
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Article
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
Mechanical forces on matrix–integrin–cytoskeleton linkages are crucial for cell viability, morphology and organ function1. The production of force depends on the molecular connections from extracellular-matrix–in...
