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Article
Novel CRISPR/Cas9-mediated knockout of LIG4 increases efficiency of site-specific integration in Chinese hamster ovary cell line
To investigate the impact of deficiency of LIG4 gene on site-specific integration in CHO cells.
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Article
Open AccessThe E3 ubiquitin ligase Itch is required for B-cell development
The E3 ubiquitin ligase Itch interacts with Foxo1 and targets it for ubiquitination and degradation during follicular helper T-cell differentiation, whereas the transcription factor Foxo1 plays a critical role...
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Article
Open AccessAn epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer
Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF) has progression-promoting potentials in certain solid tumors, which is largely attributed to the immunomodulatory function ...
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Article
Open AccessTim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2
T cell immunoglobulin mucin-3 (Tim-3) is an immune checkpoint inhibitor and its dysregulation has been related to T cell tolerance and many immune disorders, such as tumors and infection tolerance. However, th...
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Article
Open AccessMAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence
Staphylococcus aureus causes a wide range of infectious diseases. Treatment of these infections has become increasingly difficult due to the widespread emergence of antibiotic-resistant strains; therefore, it is ...
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Article
Self-similarity based editing of 3D surface textures using height and albedo maps
This paper presents an inexpensive method for self-similarity based editing of real-world 3D surface textures by using height and albedo maps. Unlike self-similarity based 2D texture editing approaches which o...
