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  1. Article

    Open Access

    Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

    Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...

    Yan He, Can-Can Zheng, **g Yang, Shu-Jun Li, Tao-Yang Xu, **an Wei… in Cell Discovery (2023)

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  2. No Access

    Article

    Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner

    Posttranslational modifications add tremendous complexity to proteomes; however, gaps remain in knowledge regarding the function and regulatory mechanism of newly discovered lysine acylation modifications. Her...

    Long Liao, Yan He, Shu-Jun Li, **ao-Mei Yu, Zhi-Chao Liu, Yi-Yao Liang… in Cell Research (2023)

  3. Article

    Open Access

    Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently needed. Here, a co...

    **ang-Peng Tan, Yan He, **g Yang, **an Wei… in Signal Transduction and Targeted Therapy (2023)

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  4. Article

    Open Access

    Targeting PI3K/Akt signal transduction for cancer therapy

    The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors. Examini...

    Yan He, Miao Miao Sun, Guo Geng Zhang… in Signal Transduction and Targeted Therapy (2021)

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  5. No Access

    Article

    Use of bionic inspired surfaces for aerodynamic drag reduction on motor vehicle body panels

    Inspired by the successful applications of biological non-smoothness, we introduced bionic non-smooth surfaces as appendices into vehicle body design, aiming to further reduce aerodynamic drag. The size range ...

    **ao-wen Song, Guo-geng Zhang, Yun Wang… in Journal of Zhejiang University-SCIENCE A (2011)