21 Result(s)

Article

Mutations associated with age-related clonal hematopoiesis in PMF patients with rapid progression to myelofibrosis

Besides histopathological findings there are no indicators of increased risk for fibrotic progression in myeloproliferative neoplasms (MPN). Age-related clonal hematopoiesis (ARCH/CHIP) is a frequent finding in t...

Stephan Bartels, Muhammad Faisal, Guntram Büsche, Jerome Schlue… in Leukemia (2020)

Article

An endothelial cell line infected by Kaposi’s sarcoma–associated herpes virus (KSHV) allows the investigation of Kaposi’s sarcoma and the validation of novel viral inhibitors in vitro and in vivo

Kaposi’s sarcoma–associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), a tumor of endothelial origin predominantly affecting immunosuppressed individuals. Up to date, vaccines and ta...

Tatyana Dubich, Anna Lieske, Susann Santag… in Journal of Molecular Medicine (2019)

Article

Peripheral blood cytogenetics allows treatment monitoring and early identification of treatment failure to lenalidomide in MDS patients: results of the LE-MON-5 trial

Transfusion-dependent patients with low- or intermediate-1-risk myelodysplastic syndrome, <5% bone marrow (BM) blasts and isolated 5q-deletion received lenalidomide within the German MDS study group phase-II c...

Friederike Braulke, Xenia Schulz, Ulrich Germing, Esther Schuler… in Annals of Hematology (2017)

Article

Leukemogenic potency of the novel FLT3-N676K mutant

The novel FMS-like tyrosine kinase 3 (FLT3)-N676K point mutation within the FLT3 kinase domain-1 was recently identified in 6 % of de novo acute myeloid leukemia (AML) patients with inv(16). Because FLT3-N676K...

Kezhi Huang, Min Yang, Zengkai Pan, Florian H. Heidel… in Annals of Hematology (2016)

Article

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

In a mouse model of the 5q- subtype of myelodysplastic syndrome, haploinsufficiency of the ribosomal protein gene Rps14 leads to anemia through a mechanism involving innate immune signaling and the Tlr4 ligand S1...

Rebekka K Schneider, Monica Schenone, Monica Ventura Ferreira… in Nature Medicine (2016)

Article

Morphology and quantitative composition of hematopoietic cells in murine bone marrow and spleen of healthy subjects

Laboratory mice play an outstanding role in modeling human development and disease. In contrast to human leukemia, the spleen is involved in almost all cases, and the bone marrow is only variably involved in m...

Min Yang, Guntram Büsche, Arnold Ganser, Zhixiong Li in Annals of Hematology (2013)

Article

Cytological characterization of murine bone marrow and spleen hematopoietic compartments for improved assessment of toxicity in preclinical gene marking models

Gene therapy has proven its potential to cure diseases of the hematopoietic system, but potential adverse reactions related to insertional mutagenesis by integrating gene vectors and chromosomal instability in...

Min Yang, Guntram Büsche, Arnold Ganser, Zhixiong Li in Annals of Hematology (2013)

Article

Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia

The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by ...

Kais Hussein, Guntram Büsche, Michaela Muth, Gudrun Göhring… in Annals of Hematology (2011)

Article

Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) — a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia

Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm showing aberrant bone marrow remodeling with increased angiogenesis, progressive matrix accumulation, and fibrosis development. Thrombospond...

Michaela Muth, Bianca M. Engelhardt, Nicolaus Kröger, Kais Hussein… in Annals of Hematology (2011)

Article

Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression

Lenalidomide consistently induces transfusion independence and complete cytogenetic response in patients with myelodysplastic syndromes with 5q deletion. Only limited information on long-term outcome is curren...

Gudrun Göhring, Aristoteles Giagounidis, Guntram Büsche… in Annals of Hematology (2010)

Article

Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies

Lck/yes-related novel (Lyn) tyrosine kinase overexpression has been suggested to be important for leukaemic cell growth making it an attractive target for therapy. By contrast, Lyn deficiency was shown to be r...

Kais Hussein, Nils von Neuhoff, Guntram Büsche, Thomas Buhr… in Annals of Hematology (2009)

Article

Meeting report: Vienna 2008 Workshop of the German–Austrian Working Group for Studying Prognostic Factors in Myelodysplastic Syndromes

Criteria, scoring systems, and treatment algorithms for myelodysplastic syndromes (MDS) have been updated repeatedly in recent years. This apparently results from increased awareness and early recognition of t...

Peter Valent, Wolf-Karsten Hofmann, Guntram Büsche, Karl Sotlar… in Annals of Hematology (2009)

Article

Complete cytogenetic remission after decitabine treatment in a patient with secondary AML harbouring high p15 ^INK4b gene methylation and high global DNA methylation

Ulrich Lehmann, Christiane Dobbelstein, Martin Fenner… in Annals of Hematology (2009)