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Chapter and Conference Paper
Application Research of Escalators Status Monitor and Forecast Based on Vibration Analysis
Escalators are special equipment. Escalators safety is closely related to the public safety. In 2011, a failure of an escalator at Bei**g Zoo Metro Station, where some passengers were injured, resulted in a v...
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Article
Open AccessMechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid
The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their app...
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Protocol
Replica Exchange Molecular Dynamics: A Practical Application Protocol with Solutions to Common Problems and a Peptide Aggregation and Self-Assembly Example
Protein aggregation is associated with many human diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and type II diabetes (T2D). Understanding the molecular mechanism of protein aggregation i...
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Article
Open AccessSingle-molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions
Research on the dynamics of single-membrane proteins remains underdeveloped due to the lack of proper approaches that can probe in real time the protein’s insertion depth in lipid bilayers. Here we report a si...
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Article
Open AccessConformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation
Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found...
