20 Result(s)

Article

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lu...

Li-Jun Liang, Fu-Ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang… in Cell Discovery (2024)

Article

Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade

Si-Chong Han, Gui-Zhen Wang, Ya-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells

Angiotensin-converting enzyme 2 (ACE2) is the receptor of COVID-19 pathogen SARS-CoV-2, but the transcription factors (TFs) that regulate the expression of the gene encoding ACE2 (ACE2) have not been systematical...

Li-jun Liang, Di Wang, Hong Yu, Jun Wang, Hui Zhang… in Acta Pharmacologica Sinica (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Author Correction: The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Gui-Zhen Wang, Li Zhang, **n-Chun Zhao, San-Hui Gao, Li-Wei Qu… in Nature Communications (2022)

Article

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, do...

Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu… in Signal Transduction and Targeted Therapy (2021)

Article

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Whether tobacco carcinogens enable exposed cells immune escape resulting in carcinogenesis, and why patients who smoke respond better to immunotherapies than non-smokers, remains poorly understood. Here we rep...

Gui-Zhen Wang, Li Zhang, **n-Chun Zhao, San-Hui Gao, Li-Wei Qu… in Nature Communications (2019)

Article

Down-regulation of microRNA-144 in air pollution-related lung cancer

Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highes...

Hong-Li Pan, Zhe-Sheng Wen, Yun-Chao Huang, **n Cheng, Gui-Zhen Wang… in Scientific Reports (2015)

Article

The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy

Invasion and metastasis are the main causes of treatment failure and death in breast cancer. Thus, novel invasion-based therapies such as those involving natural agents are urgently required. In this study, we...

Ying Liu, Wei Cao, Bo Zhang, Yong-qiang Liu, Zhong-yuan Wang… in Scientific Reports (2013)

Article

Dr. Zhen-Yi Wang: Fighting leukemia

Ming Li, Guang-Biao Zhou in Protein & Cell (2013)

Article

Healthy people, healthy journal

Sai-Juan Chen, **ao-** Chen, Guang-Biao Zhou in Frontiers of Medicine in China (2010)

Article

From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era

Leukemia is a group of heterozygous diseases of hematopoietic stem/progenitor cells that involves dynamic change in the genome. Dissection of genetic abnormalities critical to leukemia initiation provides insi...

Guang-biao Zhou, Guo Li, Sai-juan Chen, Zhu Chen in Acta Pharmacologica Sinica (2007)

Article

Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

Guang-Biao Zhou, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen in Cell Research (2007)