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    Article

    Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

    The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we show that microreactor-based pyrosequencing can det...

    Roman K Thomas, Elizabeth Nickerson, Jan F Simons, Pasi A Jänne in Nature Medicine (2006)

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    Reference Work Entry In depth

    Lats in Cell-cycle Regulation and Tumorigenesis

    Gregory S. Turenchalk, Tian Xu in Encyclopedic Reference of Cancer (2001)

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    Article

    Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

    We have previously used mosaic flies to screen for tumour suppressors or negative regulators of cell proliferation1. The cellular composition of these flies resembles that of cancer patients who are chimaeric ind...

    Wufan Tao, Sheng Zhang, Gregory S Turenchalk, Rodney A Stewart in Nature Genetics (1999)