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Article
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we show that microreactor-based pyrosequencing can det...
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Reference Work Entry In depth
Lats in Cell-cycle Regulation and Tumorigenesis
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Article
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
We have previously used mosaic flies to screen for tumour suppressors or negative regulators of cell proliferation1. The cellular composition of these flies resembles that of cancer patients who are chimaeric ind...