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Open AccessA New Index of Coordinated Posterior and Anterior Evoked EEG to Detect Recall Under Sedation – A Pilot Study
EEG-based technologies may be limited in identifying recall under sedation (RUS). We developed a novel index, posteriorization/anteriorization (P/A) index, based on auditory evoked EEG signal and assessed whet...
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The Impact of Red Blood Cell Transfusion on Cerebral Tissue Oxygen Saturation in Severe Traumatic Brain Injury
There are a range of opinions on the benefits and thresholds for the transfusion of red blood cells in critically ill patients with traumatic brain injury (TBI) and an urgent need to understand the neurophysio...
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Open AccessExperimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure
Low hemoglobin concentration (Hb) and low mean arterial blood pressure (MAP) impact outcomes in critically ill patients. We utilized an experimental model of “normotensive” vs. “hypotensive” acute hemodilution...
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Erythropoietic neuroprotection: Holy Grail or potential to fail?
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The “sticky” business of “adherence” to transfusion guidelines
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Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin–starch conjugates in rats
To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin–hydroxyethyl starch conjugate (HRC 101).
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At what point does hemodilution harm the brain?
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Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats
This study assessed the effect of oxygen affinity and molecular weight (MW) of o-raffinose cross-linked hemoglobin based oxygen carriers (HBOCs) on cerebral oxygen delivery and mean arterial blood pressure (MA...
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Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury
To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs).
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Case report: Profound hypotension associated with labetalol therapy in a patient with cerebral aneurysms and subarachnoid hemorrhage
Labetalol is an effective antihypertensive medication frequently used to treat systemic hypertension in acute care settings, including the management of hypertension associated with a subarachnoid hemorrhage. ...
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Renal expression of endothelial nitric oxide synthase after cpb in rat
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Hypocapnia attenuates mesenteric ischemia-reperfusion injury in a rat model
Hypocapnia, a recognized complication of high frequency oscillation ventilation, has multiple adverse effects on lung and brain physiologyin vivo, including potentiation of free radical injury. We hypothesized th...
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In collaboration with the Canadian Anesthesiologists’ Society, the Canadian Journal of Anesthesia is proud to publish the best abstracts presented at the Annual Meeting of the Canadian Anesthesiologists’ Society held in Quebec City, Quebec, June 18–22, 2004
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Abstract
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Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats
To test the hypotheses that deliberate elevation of PaCO2 increases cerebral tissue oxygen tension (PBrO2) by augmenting PaO2 and regional cerebral blood flow (rCBF).
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Abstract
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Successful treatment using recombinant factor VIIa for severe bleeding post cardiopulmonary bypass
To describe a case of persistent and excessive bleeding following an aortic valve and ascending aorta replacement that was successfully managed with recombinant factor VIIa (rFVIIa). The postulated mechanisms ...
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Abstract
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Abstracts
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Density determination of local anaesthetic opioid mixtures for spinal anaesthesia
To measure the density of hyperbaric and isobaric local anaesthetics before and after addition of neuroaxial opioids to define a method for calculating any local anaesthetic/opioid mixture density based on ind...
