63 Result(s)
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Gregory J. Anderson
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Article
Reproductive Biology of Asteraceae on Oceanic Islands
Asteraceae are among the most abundant angiosperm families on oceanic islands. The reproductive biology of Asteraceae is reviewed and the attributes of the family contributing to their success on islands are d...
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Article
The biology of mammalian multi-copper ferroxidases
The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis. Each of these enzymes ...
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Article
Open AccessSupplementation with Sucrosomial® iron leads to favourable changes in the intestinal microbiome when compared to ferrous sulfate in mice
Iron deficiency is one of the most common nutritional deficiencies worldwide and is often treated with oral iron supplements. However, commonly used supplements, including those based on ferrous iron salts, ar...
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Open AccessDouble-edge sword roles of iron in driving energy production versus instigating ferroptosis
Iron is vital for many physiological functions, including energy production, and dysregulated iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized form of regulated cell dea...
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Open AccessIncreased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis
Defective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early mortality in cystic fibrosis (CF). Abnormal airway iron homeostasis and...
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Open AccessUtility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis
Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis. We determined the ...
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Article
Open AccessBioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are qualified as immunoadjuvants. He...
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Article
Culinary Cultural Conservation and Cultural Keystone Food Groups: Concepts in Ethnobotany
We propose Culinary Cultural Conservation (CCC) and Cultural Keystone Food Groups (CKFG) as ethnobotanical concepts. Our two-decade study of fresh food markets showed impressive crop-consistency across space (...
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Open AccessMulti-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes
Accumulation of iron has been associated with the pathobiology of various disorders of the central nervous system. Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mi...
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Dietary iron absorption during early postnatal life
Inadequate iron levels during early life can have adverse consequences for the develo** infant. Iron deficiency during this critical period of growth can affect brain development and cognitive function, prob...
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Open AccessReversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated...
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Article
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
DNA origami-based nanorobot presents thrombin to cause tumor infarction after specific recognition of a tumor vessel marker.
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Author Correction: Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours
In the version of the Supplementary Information originally published, in Supplementary Fig. 8a, in the bottom row, the left-most image (‘Control’) was not the correct image; this has now been replaced.
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Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours
Limited intratumoural perfusion and nanoparticle retention remain major bottlenecks for the delivery of nanoparticle therapeutics into tumours. Here, we show that polymer–lipid–peptide nanoparticles delivering...
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Open AccessNasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain
Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow effici...
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Article
Genetics of floral traits of Jaltomata procumbens (Solanaceae)
Understanding the genetic control of key reproductive traits/characters facilitates better understanding of systematics and evolution. Accordingly, we employed hybridization studies to investigate the Mendelia...
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Open AccessHephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney
Multicopper ferroxidases (MCFs) play an important role in cellular iron homeostasis. However, the role of MCFs in renal metabolism remains unclear. We used Hephaestin (Heph) and Ceruloplasmin (Cp) single or doubl...
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Open AccessCorrelation of serum hepcidin levels with disease progression in hepatitis B virus-related disease assessed by nanopore film based assay
Chronic hepatitis B virus (HBV) infection often develop into cirrhosis, and both are major risk factors of hepatocellular carcinoma. However, effective approaches for the monitoring of HBV-related disease prog...
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Open AccessThe first de novo transcriptome of pepino (Solanum muricatum): assembly, comprehensive analysis and comparison with the closely related species S. caripense, potato and tomato
Solanum sect. Basarthrum is phylogenetically very close to potatoes (Solanum sect. Petota) and tomatoes (Solanum sect. Lycopersicon), two groups with great economic importance, and for...
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Breeding systems in Tolpis (Asteraceae) in the Macaronesian islands: the Azores, Madeira and the Canaries
Plants on oceanic islands often originate from self-compatible (SC) colonizers capable of seed set by self-fertilization. This fact is supported by empirical studies, and is rooted in the hypothesis that one (...
