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Open AccessA phase 3 randomised double-blind placebo-controlled trial of mirtazapine as a pharmacotherapy for methamphetamine use disorder: a study protocol for the Tina Trial
There are no approved pharmacotherapies for methamphetamine use disorder. Two preliminary phase 2 randomised controlled trials have found mirtazapine, a tetracyclic antidepressant, to be effective in reducing ...
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Open AccessA homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dyna...
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Reference Work Entry In depth
Measuring Change
We present mixed-effects regression analysis as a way to examine change over time in a descriptive and illustrative way without equations. Beginning with concepts from ordinary regression, we discuss intention...
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Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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AP-1 imprints a reversible transcriptional programme of senescent cells
Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechanisms and r...
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Author Correction: Necroptosis microenvironment directs lineage commitment in liver cancer
In this Article, the pCaMIN construct consisted of ‘mouse MYC and mouse NrasG12V’ instead of ‘mouse Myc and human NRASG12V; and the pCAMIA construct consisted of ‘mouse Myc and human AKT1’ instead of ‘mouse Myc a...
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Necroptosis microenvironment directs lineage commitment in liver cancer
Primary liver cancer represents a major health problem. It comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with regards to their morphology, metastatic...
