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Open AccessAccuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis
Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...
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Article
Open AccessClinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series
Recent alerts have highlighted an increase in group A streptococcal (GAS) infections since 2022 in Europe and the United States. Streptococcus pyogenes can cause limited skin or mucosal disease, but can also pres...
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Article
Open AccessThe interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study
Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-ce...
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Article
Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients
The human chemokine stromal cell-derived factor-1 (SDF-1) or CXCL12 is involved in several homeostatic processes and pathologies through interaction with its cognate G protein-coupled receptor CXCR4. Recent re...
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Article
Do Cerebral Cortex Perfusion, Oxygen Delivery, and Oxygen Saturation Responses Measured by Near-Infrared Spectroscopy Differ Between Patients Who Fail or Succeed in a Spontaneous Breathing Trial? A Prospective Observational Study
Alterations in perfusion to the brain during the transition from mechanical ventilation (MV) to a spontaneous breathing trial (SBT) remain poorly understood. The aim of the study was to determine whether chang...
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Article
Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study
The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults with class II o...
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Open AccessImpact of tight blood glucose control within normal fasting ranges with insulin titration prescribed by the Leuven algorithm in adult critically ill patients: the TGC-fast randomized controlled trial
It remains controversial whether critical illness-related hyperglycemia should be treated or not, since randomized controlled trials (RCTs) have shown context-dependent outcome effects. Whereas pioneer RCTs fo...
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Open AccessThe impact of extracorporeal membrane oxygenation on the exposure to isavuconazole: a plea for thorough pharmacokinetic evaluation
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Article
Open AccessAcute kidney injury in critical COVID-19: a multicenter cohort analysis in seven large hospitals in Belgium
Acute kidney injury (AKI) has been reported as a frequent complication of critical COVID-19. We aimed to evaluate the occurrence of AKI and use of kidney replacement therapy (KRT) in critical COVID-19, to asse...
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Article
Open AccessPersisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness
Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...
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Article
Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study
To evaluate aerobic exercise capacity in 5-year intensive care unit (ICU) survivors and to assess the association between severity of organ failure in ICU and exercise capacity up to 5-year follow-up.
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Open AccessClinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradic...
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Article
Impact of COVID-19: urging a need for multi-domain assessment of COVID-19 inpatients
To retrospectively analyse data obtained from the multi-domain assessment of hospitalized COVID-19 patients, to describe their health status at discharge, and to investigate whether subgroups of patients, more...
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Article
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduce...
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Open AccessDiscriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL...
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Weakness in the ICU: the right weight on the right scale
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Intensive care unit acquired muscle weakness in COVID-19 patients
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Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study
To assess the independent association between ICU-acquired neuromuscular complications and 5-year mortality and morbidity. To explore the optimal threshold of the Medical Research Council (MRC) sum score, asse...
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Critical Illness Neuromyopathy: Clinical, Electrophysiological, and Histological Diagnosis
Acute neuromuscular complications are common during critical illness, particularly among the most severe intensive care unit (ICU) patients with prolonged stay and mechanical ventilation, and those develo** ...
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The urea-creatinine ratio as a novel biomarker of critical illness-associated catabolism