28 Result(s)

Article

Accuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis

Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...

Diego Poddighe, Marine Van Hollebeke, Yasir Qaiser Choudhary… in Critical Care (2024)

Article

Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

Recent alerts have highlighted an increase in group A streptococcal (GAS) infections since 2022 in Europe and the United States. Streptococcus pyogenes can cause limited skin or mucosal disease, but can also pres...

Marijke Peetermans, Veerle Matheeussen, Cedric Moerman… in Annals of Intensive Care (2024)

Article

The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-ce...

Senta Jorinde Raasveld, Claudia van den Oord, Jimmy Schenk… in Critical Care (2023)

Article

Do Cerebral Cortex Perfusion, Oxygen Delivery, and Oxygen Saturation Responses Measured by Near-Infrared Spectroscopy Differ Between Patients Who Fail or Succeed in a Spontaneous Breathing Trial? A Prospective Observational Study

Alterations in perfusion to the brain during the transition from mechanical ventilation (MV) to a spontaneous breathing trial (SBT) remain poorly understood. The aim of the study was to determine whether chang...

Zafeiris Louvaris, Marine Van Hollebeke, Diego Poddighe… in Neurocritical Care (2023)

Article

Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study

The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults with class II o...

Marijke Peetermans, Ipek Guler, Philippe Meersseman… in Intensive Care Medicine (2023)

Article

Impact of tight blood glucose control within normal fasting ranges with insulin titration prescribed by the Leuven algorithm in adult critically ill patients: the TGC-fast randomized controlled trial

It remains controversial whether critical illness-related hyperglycemia should be treated or not, since randomized controlled trials (RCTs) have shown context-dependent outcome effects. Whereas pioneer RCTs fo...

Jan Gunst, Liese Mebis, Pieter J. Wouters, Greet Hermans, Jasperina Dubois… in Trials (2022)

Article

The impact of extracorporeal membrane oxygenation on the exposure to isavuconazole: a plea for thorough pharmacokinetic evaluation

Beatrijs Mertens, Joost Wauters, Yves Debaveye, Niels Van Regenmortel… in Critical Care (2022)

Article

Acute kidney injury in critical COVID-19: a multicenter cohort analysis in seven large hospitals in Belgium

Acute kidney injury (AKI) has been reported as a frequent complication of critical COVID-19. We aimed to evaluate the occurrence of AKI and use of kidney replacement therapy (KRT) in critical COVID-19, to asse...

Hannah Schaubroeck, Wim Vandenberghe, Willem Boer, Eva Boonen, Bram Dewulf… in Critical Care (2022)

Article

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...

Ilse Vanhorebeek, Inge Derese, Jan Gunst, Pieter J. Wouters, Greet Hermans… in Critical Care (2021)

Article

Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study

To evaluate aerobic exercise capacity in 5-year intensive care unit (ICU) survivors and to assess the association between severity of organ failure in ICU and exercise capacity up to 5-year follow-up.

Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye… in Intensive Care Medicine (2021)

Article

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host

Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradic...

Verónica Lloréns-Rico, Ann C. Gregory, Johan Van Weyenbergh… in Nature Communications (2021)

Article

Impact of COVID-19: urging a need for multi-domain assessment of COVID-19 inpatients

To retrospectively analyse data obtained from the multi-domain assessment of hospitalized COVID-19 patients, to describe their health status at discharge, and to investigate whether subgroups of patients, more...

Arne Heyns, Jolan Dupont, Evelien Gielen, Johan Flamaing… in European Geriatric Medicine (2021)

Article

Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial

Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduce...

Lore Vanderbeke, Nico A. F. Janssen, Dennis C. J. J. Bergmans… in Intensive Care Medicine (2021)

Article

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL...

Els Wauters, Pierre Van Mol, Abhishek Dinkarnath Garg, Sander Jansen… in Cell Research (2021)

Article

Intensive care unit acquired muscle weakness in COVID-19 patients

Nathalie Van Aerde, Greet Van den Berghe, Alexander Wilmer… in Intensive Care Medicine (2020)

Article

The urea-creatinine ratio as a novel biomarker of critical illness-associated catabolism

Jan Gunst, Kianoush B. Kashani, Greet Hermans in Intensive Care Medicine (2019)

Article

The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT

Invasive fungal infections (IFI) are difficult to diagnose, especially in critically ill patients. As the mannose receptor (MR) is shed from macrophage cell surfaces after exposure to fungi, we investigate whe...

Greet De Vlieger, Ilse Vanhorebeek, Pieter J. Wouters, Inge Derese… in Critical Care (2019)

Article

Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT

The majority of critically ill patients do not suffer from acute respiratory distress syndrome (ARDS). To improve the treatment of these patients, we aimed to identify potentially modifiable factors associated...

Fabienne D. Simonis, Carmen S. V. Barbas… in Annals of Intensive Care (2018)

Article

The ICM research agenda on intensive care unit-acquired weakness

We present areas of uncertainty concerning intensive care unit-acquired weakness (ICUAW) and identify areas for future research. Age, pre-ICU functional and cognitive state, concurrent illness, frailty, and he...

Nicola Latronico, Margaret Herridge, Ramona O. Hopkins… in Intensive Care Medicine (2017)

Article

Lectin pathway of complement activation and relation with clinical complications in critically ill children

Critically ill children are susceptible to nosocomial infections, which contribute to adverse outcomes. Deficiencies in the innate immunity lectin pathway of complement activation are implicated in a child’s v...

Catherine Ingels, Ilse Vanhorebeek, Rudi Steffensen, Inge Derese… in Pediatric Research (2014)