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Open AccessThe treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery
This Position Statement updates the different components of the therapy of obesity (lifestyle intervention, drugs, and surgery) in children and adolescents, previously reported in the consensus position statem...
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Article
Open AccessThe neutrophil to lymphocyte ratio (NLR) positively correlates with the presence and severity of metabolic syndrome in obese adults, but not in obese children/adolescents
Metabolic syndrome (MetS) associated with obesity is a pathological condition increasing worldwide. Recent studies have demonstrated that the neutrophil to lymphocyte ratio (NLR) can be successfully used to st...
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Article
Open AccessThe Italian registry for patients with Prader–Willi syndrome
Prader–Willi syndrome (PWS) is a rare and complex genetic disease, with numerous implications on metabolic, endocrine, neuropsychomotor systems, and with behavioural and intellectual disorders. Rare disease pa...
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Open AccessAuthor Correction: Predictive factors of responsiveness to a body weight reduction program in Prader–Willi patients at 6 years of follow‑up
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Open AccessPredictive factors of responsiveness to a body weight reduction program in Prader–Willi patients at 6 years of follow-up
Prader–Willi syndrome (PWS), a multisystemic disorder caused by lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region, is characterized by hyperphagia and childhood-onset morbid...
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Gait strategy and body composition in patients with Prader–Willi syndrome
Individuals with Prader–Willi syndrome (PWS) exhibit reduced lean body mass and increased fat–lean mass ratio when compared with individuals of normal weight and obese ones. Thus, research on the association o...
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Update on Diabetes Mellitus and Glucose Metabolism Alterations in Prader-Willi Syndrome
This review summarizes our current knowledge on type 2 diabetes mellitus (T2DM) and glucose metabolism alterations in Prader-Willi syndrome (PWS), the most common syndromic cause of obesity, and serves as a gu...
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Open AccessIrisin levels in genetic and essential obesity: clues for a potential dual role
Irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. Its potential link to fat accumulation and metabolic dysfunction is de...
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Article
Autoimmune pituitary involvement in Prader–Willi syndrome: new perspective for further research
The role of antipituitary antibodies in the pathophysiology of pituitary hormone deficiency has been increasingly elucidated over the last decade. Prader-Willi syndrome is a genetic disorder which includes hyp...
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Article
Open AccessDiagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics
The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to th...
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Article
Open AccessCongenital hypothyroidism due to ectopic sublingual thyroid gland in Prader-Willi Syndrome: a case report
Thyroid gland disorders are variably associated with Prader-Willi syndrome (PWS).
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Article
Open AccessCirculating angiopoietin-like 8 (ANGPTL8) is a marker of liver steatosis and is negatively regulated by Prader-Willi Syndrome
ANGPTL8 is a liver-derived protein related to insulin-sensitivity. Its relationship with obesity and liver function in Prader-Willi syndrome (PWS) is unknown. The present study investigated circulating ANGPTL8...
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Open AccessGait initiation and termination strategies in patients with Prader-Willi syndrome
Gait Initiation (GI) is a functional task representing one of the first voluntary destabilizing behaviours observed in the development of a locomotor pattern as the whole body centre of mass transitions from a...
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Article
The rehabilitation of children and adolescents with severe or medically complicated obesity: an ISPED expert opinion document
Severe/medically complicated obesity in childhood, and particularly in adolescence, is a real disability that requires an intensive and continuous approach which should follow the procedures and schedule of re...
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Article
Open AccessChildhood obesity classification systems and cardiometabolic risk factors: a comparison of the Italian, World Health Organization and International Obesity Task Force references
Body Mass Index Italian reference data are available for clinical and/or epidemiological use, but no study compared the ability of this system to classify overweight and obesity and detect subjects with cluste...
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Article
Triglycerides-to-HDL cholesterol ratio as screening tool for impaired glucose tolerance in obese children and adolescents
To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5–10 years) and adolescents (n = 531, age 10–17.9 year).
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Adults with Prader–Willi Syndrome have Weaker Bones: Effect of Treatment with GH and Sex Steroids
Obesity has been considered to have a protective effect against the risk of fractures in adults. However, a high frequency of fracture is described in obese adults with Prader–Willi syndrome. To evaluate bone ...
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Prader–Willi syndrome—GH therapy and bone
A recent publication in the Journal of Clinical Endocrinology and Metabolism provides new data about the role of growth hormone (GH) in bone in Prader–Willi syndrome. The lack of positive effects of long-term GH ...
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Open AccessFractal dimension approach in postural control of subjects with Prader-Willi Syndrome
Static posturography is user-friendly technique suitable for the study of the centre of pressure (CoP) trajectory. However, the utility of static posturography in clinical practice is somehow limited and there...
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Article
Open AccessPostural adaptations to long-term training in Prader-Willi patients
Improving balance and reducing risk of falls is a relevant issue in Prader-Willi Syndrome (PWS). The present study aims to quantify the effect of a mixed training program on balance in patients with PWS.
