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  1. Article

    Open Access

    Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

    Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and analogues block cancer cell “stemness”, orga...

    Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb… in Nature Communications (2022)

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  2. Article

    Retraction Note: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli… in Nature (2020)

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    Article

    Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation

    Signal transducer and activator of transcription 3 (STAT3) has a critical role in regulating cell fate, inflammation and immunity1,2. Cytokines and growth factors activate STAT3 through kinase-mediated tyrosine p...

    Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli… in Nature (2019)

  4. No Access

    Article

    ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

    The use of activity-based chemical probes revealed that Scribble is palmitoylated at cysteine residues by the palmitoyl acyltransferase ZDHHC7. Loss of Scribble palmitoylation results in loss of cell polarity ...

    Baoen Chen, Baohui Zheng, Michael DeRan, Gopala K Jarugumilli… in Nature Chemical Biology (2016)

  5. No Access

    Article

    Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

    Biochemical assays using activity-based chemical probes revealed that the Hippo pathway transcription factor TEAD undergoes autopalmitoylation to ensure binding to YAP/TAZ and promote muscle differentiation a...

    PuiYee Chan, **ao Han, Baohui Zheng, Michael DeRan, Jianzhong Yu… in Nature Chemical Biology (2016)