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  1. Article

    Open Access

    Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

    As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate hypothalamic neuropeptide systems have shown promise in preclinical...

    Giuseppe Giannotti, Francesca Mottarlini, Jasper A. Heinsbroek… in Translational Psychiatry (2022)

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    Article

    Ketamine Self-Administration Elevates αCaMKII Autophosphorylation in Mood and Reward-Related Brain Regions in Rats

    Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be a...

    Lucia Caffino, Alessandro Piva, Francesca Mottarlini… in Molecular Neurobiology (2018)

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    Article

    Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain

    Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and reinforcing properties, although recent work has pointed out its antidepressant action following acute exposure....

    Lucia Caffino, Alessandro Piva, Giuseppe Giannotti… in Molecular Neurobiology (2017)

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    Article

    The Cathinones MDPV and α-PVP Elicit Different Behavioral and Molecular Effects Following Acute Exposure

    Since the mid-to-late 2000s, synthetic cathinones have gained popularity among drug users due to their psychostimulant effects greater than those produced by cocaine and amphetamine. Among them, 3,4-methylened...

    Giuseppe Giannotti, Isabella Canazza, Lucia Caffino… in Neurotoxicity Research (2017)

  5. No Access

    Article

    A single cocaine exposure disrupts actin dynamics in the cortico-accumbal pathway of adolescent rats: modulation by a second cocaine injection

    Among the changes caused by repeated exposure to drugs of abuse, structural rearrangements play a critical role, setting the stage for maladaptive responses to environmental challenges and sustaining drug-taki...

    Lucia Caffino, Giuseppe Giannotti, Giorgio Racagni, Fabio Fumagalli in Psychopharmacology (2017)

  6. No Access

    Article

    Developmental Exposure to Cocaine Dynamically Dysregulates Cortical Arc/Arg3.1 Modulation in Response to a Challenge

    During adolescence, the medial prefrontal cortex (mPFC) is still develo**. We have previously shown that developmental cocaine exposure alters mPFC’s ability to cope with challenging events. In this manuscri...

    Lucia Caffino, Giuseppe Giannotti, Francesca Mottarlini… in Neurotoxicity Research (2017)

  7. No Access

    Article

    Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently

    Although brain-derived neurotrophic factor (BDNF) is part of a homeostatic pathway involved in the development of alcohol dependence, it is not clear whether this is also true after recreational ethanol consum...

    Alessandro Orrù, Lucia Caffino, Federico Moro, Chiara Cassina… in Psychopharmacology (2016)

  8. No Access

    Article

    Region-specific effects of developmental exposure to cocaine on fibroblast growth factor-2 expression in the rat brain

    Adolescence is a period of high vulnerability to drugs of abuse and alterations of the proper developmental trajectory via psychostimulant exposure might change the physiological brain homeostasis.

    Giuseppe Giannotti, Lucia Caffino, Francesca Mottarlini… in Psychopharmacology (2016)

  9. No Access

    Article

    A single exposure to cocaine during development elicits regionally-selective changes in basal basic Fibroblast Growth Factor (FGF-2) gene expression and alters the trophic response to a second injection

    During adolescence, the brain is maturing and more sensitive to drugs of abuse that can influence its developmental trajectory. Recently, attention has been focused on basic fibroblast growth factor (FGF-2) gi...

    Giuseppe Giannotti, Lucia Caffino, Chiara Malpighi, Simona Melfi… in Psychopharmacology (2015)

  10. No Access

    Article

    Long-Term Abstinence from Developmental Cocaine Exposure Alters Arc/Arg3.1 Modulation in the Rat Medial Prefrontal Cortex

    Cocaine is a psychostimulant whose abuse causes a social and economic burden for our society. Most of the published literature deals with acute effects of cocaine or short-term abstinence in adult animals but ...

    Lucia Caffino, Giuseppe Giannotti, Chiara Malpighi… in Neurotoxicity Research (2014)

  11. No Access

    Article

    Dynamic modulation of basic Fibroblast Growth Factor (FGF-2) expression in the rat brain following repeated exposure to cocaine during adolescence

    Our study stems from four related lines of evidence: (1) FGF-2 is expressed in the develo** brain; (2) psychostimulants modulate FGF-2 expression; (3) stress alters FGF-2 expression; and (4) exogenous admini...

    Giuseppe Giannotti, Lucia Caffino, Francesca Calabrese… in Psychopharmacology (2013)