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Article
Late-onset multiple sclerosis: disability trajectories in relapsing–remitting patients of the Italian MS Registry
Generally infrequent, multiple sclerosis (MS) with late onset (LOMS) is characterized by an onset over the age of 50 and a mainly progressive course, while relapsing–remitting (RR) forms are less frequently ob...
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Article
Ocrelizumab use in multiple sclerosis: a real-world experience in a changing therapeutic scenario
CD20-depleting therapies are a real milestone in the treatment of multiple sclerosis (MS). This study examined the ocrelizumab (OCR) use in patients with primary progressive (PP) and relapsing remitting (RR) M...
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Article
Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry
Active relapsing–remitting (RR) and secondary progressive (SP) multiple sclerosis (MS) are currently defined as “relapsing MS” (RMS). The aim of this cross-sectional study was to assess drivers of treatment sw...
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Article
Open AccessTranslocations of threatened plants in the Mediterranean Basin: current status and future directions
The Mediterranean Basin is one of the World’s plant diversity hotspots and a region prone to several anthropic pressures, besides being one of the World’s areas most susceptible to climate change. In this regi...
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Article
Open AccessEvaluation of antibody response to BNT162b2 mRNA COVID-19 vaccine in patients affected by immune-mediated inflammatory diseases up to 5 months after vaccination
SARS-CoV-2 vaccination with mRNA product BNT162b2 elicited high immunogenicity in healthy subjects in trials. This study aims to better understand the factors that influence the humoral immune response to vacc...
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Article
Open AccessAssessing the potential for restoring Mediterranean coastal dunes under pressure from tourism
Mediterranean dune systems have undergone a large reduction in the last decades. The main factors involved in this process are urbanisation promoting an alteration of dune morphology and changes in plant commu...
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Article
Open AccessEffects of Pregnancy and Breastfeeding on Clinical Outcomes and MRI Measurements of Women with Multiple Sclerosis: An Exploratory Real-World Cohort Study
Pregnancy represents an important event for women with multiple sclerosis (MS) and is often accompanied by post-partum disease reactivation. To date, the influence of this reproductive phase on long-term MS ou...
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Article
What happens after fingolimod discontinuation? A multicentre real-life experience
To analyse the course of multiple sclerosis (MS) after fingolimod withdrawal in a multicentre cohort.
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Article
Recruitment pattern in an isolated small population of the Mediterranean dwarf shrub Satureja thymbra L. and implication for conservation
The recruitment pattern of Satureja thymbra (Lamiaceae), in a single and isolated population in Sardinia, was experimentally investigated by human-mediated sowing in the field: 12 plants in two habitats (inside a...
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Article
Open AccessFrom global to local scale: where is the best for conservation purpose?
Demographic analysis of plant populations represents an essential conservation tool allowing to identify the population trends both at global and at the local level. In this study, the population dynamics of Heli...
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Article
Outcomes after fingolimod to alemtuzumab treatment shift in relapsing–remitting MS patients: a multicentre cohort study
A high reactivation of multiple sclerosis (MS) was reported in patients treated with alemtuzumab after fingolimod. We aimed to understand whether this shift enhanced the risk for reactivation in a real-life c...
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Article
Assessing the Metabolomic Profile of Multiple Sclerosis Patients Treated with Interferon Beta 1a by 1H-NMR Spectroscopy
Metabolomic research has emerged as a promising approach to identify potential biomarkers in multiple sclerosis (MS). The aim of the present study was to determine the effect of interferon beta (IFN ß) on the ...
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Article
Efficacy and safety of alemtuzumab in a real-life cohort of patients with multiple sclerosis
No postmarketing randomised clinical trials are available about alemtuzumab, and real-world data are limited. We aimed to analyse the efficacy and safety of alemtuzumab in a single-centre cohort of patients wi...
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Article
The unpredictable fate of the single population of a threatened narrow endemic Mediterranean plant
Narrow endemic plants are highly vulnerable to extinction due to natural factors and human disturbance because of their restricted distribution and few populations. To conserve narrow endemic and threatened pl...
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Article
Estimating land market values from real estate offers: A replicable method in support of biodiversity conservation strategies
While cost estimation is a very positive tool for spatial conservation prioritisation, there are few examples where costs (in monetary terms) are applied. We present a repeatable method to estimate and map fie...
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Article
Litter decomposition: effects of temperature driven by soil moisture and vegetation type
We examined the importance of litter quality and microclimate on early-stage litter mass loss, analysed the importance of interactions among environmental factors in determining key decomposition parameters an...
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Article
The impact of climatic variations on the reproductive success of Gentiana lutea L. in a Mediterranean mountain area
Increases in temperature have been predicted and reported for the Mediterranean mountain ranges due to global warming and this phenomenon is expected to have profound consequences on biodiversity and ecosystem...
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Article
Fatigue, as measured using the Modified Fatigue Impact Scale, is a predictor of processing speed improvement induced by exercise in patients with multiple sclerosis: data from a randomized controlled trial
Few studies have evaluated the impact of physical activity (PA) on cognition and fatigue, and none have considered the effects of PA on the relationship between cognition and fatigue.
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Article
Open AccessA cross-sectional and longitudinal study evaluating brain volumes, RNFL, and cognitive functions in MS patients and healthy controls
The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and ...
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Article
Autoimmune comorbidities in multiple sclerosis: what is the influence on brain volumes? A case–control MRI study
Several studies indicated that multiple sclerosis (MS) is frequently associated with other autoimmune diseases. However, it is little known if the coexistence of these conditions may influence the radiologic f...
