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Article
Open AccessImpact of trans-stent gradient on outcome after PCI: results from a HAWKEYE substudy
To test whether quantitative flow ratio (QFR)-based trans-stent gradient (TSG) is associated with adverse clinical events at follow-up. A post-hoc analysis of the multi-center HAWKEYE study was performed. Vess...
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Article
Open AccessAngio-Based Fractional Flow Reserve, Functional Pattern of Coronary Artery Disease, and Prediction of Percutaneous Coronary Intervention Result: a Proof-of-Concept Study
Wire-based coronary physiology pullback performed before percutaneous coronary intervention (PCI) discriminates coronary artery disease (CAD) distribution and extent, and is able to predict functional PCI resu...
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Article
Open AccessPirfenidone as a novel cardiac protective treatment
Myocardial fibrosis is a common feature of several heart diseases. The progressive deposition of extracellular matrix due to a persistent injury to cardiomyocytes may trigger a vicious cycle that leads to pers...
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Article
Open AccessDecoding empagliflozin’s molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence
The use of sodium-glucose co-transporter 2 inhibitors to treat heart failure with preserved ejection fraction (HFpEF) is under investigation in ongoing clinical trials, but the exact mechanism of action is unc...
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Article
Open AccessMortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018
To assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (...
