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Article
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activi...
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Article
Open AccessConformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET
Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function req...
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Article
Open AccessChanges in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome
WW domains are small domains present in many human proteins with a wide array of functions and acting through the recognition of proline-rich sequences. The WW domain belonging to polyglutamine tract-binding p...
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Article
Open Access11th German Conference on Chemoinformatics (GCC 2015)
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Article
Open AccessConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase
Understanding the conformational changes associated with the binding of small ligands to their biological targets is a fascinating and meaningful question in chemistry, biology and drug discovery. One of the m...
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Article
Open AccessAn Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase
Phosphorylation of the activation loop is a fundamental step in the activation of most protein kinases. In the case of the Src tyrosine kinase, a prototypical kinase due to its role in cancer and its historic ...
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Article
In silico design of tubulin-targeted antimitotic peptides
Microtubules are polymeric structures formed by the self-assembly of tubulin dimers. The growth and shrinkage of these dynamic arrays have a key role during the cell-proliferation process. This makes tubulin t...
