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Article
Open AccessProtective effects of vitamin D3 on fimbrial cells exposed to catalytic iron damage
Recently, vitamin D3 (1alpha, 25-dihydroxyvitamin D) has shown its capability to take part in many extraskeletal functions and its serum levels have been related to patient survival rate and malignancy of many ty...
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Article
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases
Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients’ survival in a retrospective series of 128 CC and PS endometrial cancer cases.
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Article
A tag-less method for direct isolation of human umbilical vein endothelial cells by gravitational field-flow fractionation
The analysis of cellular and molecular profiles represents a powerful tool in many biomedical applications to identify the mechanisms underlying the pathological changes. The improvement of cellular starting m...
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Article
Procedure for rapid oocyte selection based on quantitative analysis of cumulus cell gene expression
To develop a procedure for the analysis of gene expression in cumulus cells during the interval between ovum pick up and insemination to select the best oocytes for fertilization.
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Article
Tectonic and sedimentary evolution of the Lower Pliocene Periadriatic foredeep in Central Italy
The Periadriatic foredeep (Italy) was generated by Neogene downbending of the Adria Plate under the Apennine Chain. The basin is filled with Plio-Pleistocene siliciclastic turbidites. Its substratum consists o...
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Article
Approaches to implement bispecific antibody treatment of ovarian carcinoma
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Article
Ergoline Derivatives as a Probe for Featuring the 5-HT1A Receptor Pharmacophore
A 5-HT1A pharmacophore has been obtained employing a set of rigid templates encompassing the 5-HT1A structure. The use of rigid templates allowed us to overcome the discrepancy found when flexible structures whe...
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Article
A machine learning approach to computer-aided molecular design
Preliminary results of a machine learning application concerning computer-aided molecular design applied to drug discovery are presented. The artificial intelligence techniques of machine learning use a sample...
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Article
Hexamethylmelamine, adriamycin, and cyclophosphamide (HAC) versus cis-dichlorodiamineplatinum, adriamycin, and cyclophosphamide (PAC) in advanced ovarian cancer: A randomized clinical trial
After stratification according to diameter of the largest residual tumor, 120 previously untreated ovarian cancer patients were randomized to receive adriamycin and cyclophosphamide in combination with hexamet...
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Combination of Adriamycin and Bleomycin in the Treatment of Advanced Cervical Cancer
Squamous cell carcinoma of the cervix has been seldom treated by chemotherapy and has usually had a low response rate with short duration. Among the drugs that gave the best results in the treatment of this ca...