7 Result(s)
within
Gian Paolo Spinelli
Biomedicine
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Article
Open AccessNetwork approach in liquidomics landscape
Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed, being too invasive with the risk of side effects. These limits ...
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Article
Open AccessBRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors
Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available...
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Article
Correlation between fertility drugs use and malignant melanoma incidence: the state of the art
The relationship between fertility, reproductive hormones, and risk of malignant melanoma has acquired much interest in recent years. Melanocytes are hormonally responsive cells, and some in vitro studies demonst...
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Article
Open AccessLarge cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features
Extraneural metastases (ENM) rarely occur in medulloblastoma (MBL) patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prog...
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Chapter
Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin
The standard pre-operative treatment of rectal cancer consists of radiotherapy combined with continuous infusion of fluorouracil (FU) at a dose of 200 mg/m2/day. Platinum compounds can increase the anti-tumour ac...
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Article
Open AccessPositron Emission Tomography (PET) radiotracers in oncology – utility of 18F-Fluoro-deoxy-glucose (FDG)-PET in the management of patients with non-small-cell lung cancer (NSCLC)
PET (Positron Emission Tomography) is a nuclear medicine imaging method, frequently used in oncology during the last years. It is a non-invasive technique that provides quantitative in vivo assessment of physi...
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Article
Open AccessA phase II trial of a biweekly combination of paclitaxel and gemcitabine in metastatic breast cancer
Many emerging new drugs have recently been trialled for treatment of early and advanced breast cancer. Among these new agents paclitaxel and gemcitabine play a crucial role, mostly in patients with relapsed an...
