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Open AccessUpdate on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment
Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients exp...
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Correlation between fertility drugs use and malignant melanoma incidence: the state of the art
The relationship between fertility, reproductive hormones, and risk of malignant melanoma has acquired much interest in recent years. Melanocytes are hormonally responsive cells, and some in vitro studies demonst...
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Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis
Originally, colorectal cancer (CRC) tumorigenesis was understood as a multistep process that involved accumulation of tumor suppressor genes and oncogenes mutations, such as APC, TP53 and KRAS. However, this assu...
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Article
Open AccessFertility drugs, reproductive strategies and ovarian cancer risk
Several adverse effects have been related to infertility treatments, such as cancer development. In particular, the relationship between infertility, reproductive strategies, and risk of gynecological cancers ...
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Article
Open AccessAn unusual case of spleen metastasis from carcinoma ex pleomorphic adenoma of the parotid gland
Carcinoma ex pleomorphic adenoma is a rare tumor arising from the salivary glands that spreads through direct extension, through the lymphatic vessels, and, rarely, hematogenously. When distant metastases have...
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Article
Open AccessEmerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach
In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...
