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Article
Open AccessEffects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle
The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area o...
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Article
Open AccessBacterial load slopes represent biomarkers of tuberculosis therapy success, failure, and relapse
There is an urgent need to discover biomarkers that are predictive of long-term TB treatment outcomes, since treatment is expense and prolonged to document relapse. We used mathematical modeling and machine le...
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Article
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions
Tuberculosis (TB) is the leading cause of death from a single infectious agent, requiring at least 6 months of multidrug treatment to achieve cure1. However, the lack of reliable data on antimicrobial pharmacokin...
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Article
Open AccessA trade-off between dry season survival longevity and wet season high net reproduction can explain the persistence of Anopheles mosquitoes
Plasmodium falciparum malaria remains a leading cause of death in tropical regions of the world. Despite efforts to reduce transmission, rebounds associated with the persistence of malaria vectors have remained a...
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Article
Open AccessInferring biomarkers for Mycobacterium avium subsp. paratuberculosis infection and disease progression in cattle using experimental data
Available diagnostic assays for Mycobacterium avium subsp. paratuberculosis (MAP) have poor sensitivities and cannot detect early stages of infection, therefore, there is need to find new diagnostic markers for e...
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Article
Open AccessA comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection
The presence of an asymptomatic phase in an HIV infection indicates that the immune system can partially control the infection. Determining the immune mechanisms that contribute significantly to the partial co...
