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Article
Open AccessSafety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myo...
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Article
Open AccessElectrophysiological Profile of Different Antiviral Therapies in a Rabbit Whole-Heart Model
Antiviral therapies for treatment of COVID-19 may be associated with significant proarrhythmic potential. In the present study, the potential cardiotoxic side effects of these therapies were evaluated using a ...
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Article
Open AccessRelevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in othe...
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Article
Open AccessMortality and rehospitalization in patients with pre-existing implantable pacemakers undergoing catheter ablation are related to increased comorbidity burden—data from the German Ablation Registry
Catheter ablation of atrial fibrillation and atrial flutter is routinely performed in patients with implantable devices. The aim of the present study was to assess success rates and potential complications in ...
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Article
Open AccessFeasibility and efficacy of a novel size adjustable cryoballoon for ablation of atrial fibrillation
The aim of the present case series was to characterize the feasibility of a novel size adjustable cryoballoon system (PolarX Fit, Boston Scientific, Marlborough, MA, USA). This cryoballoon catheter can be infl...
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Article
Open AccessAntiarrhythmic Treatment in Heart Failure
Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review curren...
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Article
Open AccessTemperature to time Catch-Up: a novel procedural endpoint to predict durable pulmonary vein isolation after cryoballoon ablation of paroxysmal atrial fibrillation
Cryoballoon ablation is a widely used single-shot technique for pulmonary vein isolation (PVI) in the treatment of paroxysmal atrial fibrillation (AF). Procedural endpoints ensuring maximal PVI durability are ...
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Article
Open AccessOutcome of patients with idiopathic ventricular fibrillation and correlation with ECG markers of early repolarization
Early repolarization pattern (ERP) has been associated with idiopathic ventricular fibrillation (IVF) and with cardiovascular mortality in the general population. As there is limited data about long- term outc...
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Article
Predictors for major in-hospital complications after catheter ablation of ventricular arrhythmias: validation and modification of the Risk in Ventricular Ablation (RIVA) Score
Catheter-based treatment of patients with ventricular arrhythmias (VA) reduces VA and mortality in selected patients. With regard to potential risks of catheter ablation, a benefit–risk assessment should be ca...
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Article
Open AccessVentricular arrhythmia burden in ICD patients during the second wave of the COVID-19 pandemic
COVID-19 has been associated with cardiovascular complications including ventricular arrhythmias (VA) and an increased number of out-of-hospital cardiac arrests. Nevertheless, several authors described a decre...
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Article
Open AccessDetecting atrial fibrillation in the polysomnography-derived electrocardiogram: a software validation study
The present study validated a software-based electrocardiogram (ECG) analysis tool for detection of atrial fibrillation (AF) and risk for AF using polysomnography (PSG)-derived ECG recordings.
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Article
Die neue ESC-Leitlinie zum Management ventrikulärer Tachyarrhythmien
Die vor Kurzem veröffentlichte Leitlinie der European Society of Cardiology (ESC) für das Management von Patienten mit ventrikulären Arrhythmien (VA) und zur Prävention des plötzlichen Herztodes aktualisiert d...
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Article
Elektromagnetische Interferenzen bei 3-D-Map**verfahren
Katheterablationen sind heute ein weit verbreitetes Verfahren zur Behandlung von Herzrhythmusstörungen. Hierfür sind genaue anatomische Kenntnisse sowohl im Vorfeld als auch während der Untersuchung erforderli...
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Article
Anatomie des linken Ventrikels als Grundlage für endokardiale Ablationen
Die Durchführung einer linksventrikulären Ablation setzt, wie bei grundsätzlich allen kardialen Interventionen, eine gute Kenntnis der kardialen Anatomie voraus. Ziel dieses Artikels ist es, eine Übersicht übe...
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Article
Open AccessSafe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models
Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology. However, experimental data is sparse. Therefore, purpose of this study was to investigate the influence of dexmedetomidine on...
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Article
Ocular perfusion in patients with reduced left ventricular ejection fraction measured by optical coherence tomography angiography
The aim of this study is to evaluate retinal and optic nerve head (ONH) perfusion in patients with systolic chronic heart failure (CHF) compared to healthy control subjects.
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Article
Open AccessPitfalls of the S-ICD therapy: experiences from a large tertiary centre
The subcutaneous ICD (S-ICD) has evolved to a potential first option for many patients who have to be protected from sudden cardiac death. Many trials have underlined a similar performance regarding its effect...
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Article
Open AccessProspective blinded evaluation of smartphone-based ECG for differentiation of supraventricular tachycardia from inappropriate sinus tachycardia
Supraventricular tachycardias (SVT) are often difficult to document due to their intermittent, short-lasting nature. Smartphone-based one-lead ECG monitors (sECG) were initially developed for the diagnosis of ...
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Article
Open AccessPredictors of response to cardiac resynchronization therapy in patients with chronic right ventricular pacing
The benefits of de novo cardiac resynchronization therapy (CRT) in patients with QRS-prolongation and impaired left-ventricular function (LVEF) are well established. Current guidelines also recommend CRT-upgra...
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Article
Divergent Electrophysiological Effects of Loperamide and Naloxone in a Sensitive Whole-Heart Model
Several case reports suggest QT prolongation leading to ventricular arrhythmias with fatal outcome after intoxication with the μ-opioid receptor agonist and anti-diarrheal agent loperamide. The number of cases...
