-
Article
Open AccessComputational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies
The role of immune cells in collagen degradation within the tumor microenvironment (TME) is unclear. Immune cells, particularly tumor-infiltrating lymphocytes (TILs), are known to alter the extracellular matri...
-
Article
Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation
Oropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology.
-
Article
Open AccessDeep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer
The tumor immune composition influences prognosis and treatment sensitivity in lung cancer. The presence of effective adaptive immune responses is associated with increased clinical benefit after immune checkp...
-
Article
Open AccessComputational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer
Prognostic markers currently utilized in clinical practice for estrogen receptor-positive (ER+) and lymph node-negative (LN−) invasive breast cancer (IBC) patients include the Nottingham grading system and Onc...
-
Article
Open AccessImage analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome
Despite known histological, biological, and clinical differences between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), relatively little is known about the spatial differences in their corresp...
-
Chapter and Conference Paper
A Web-Based Telepathology Framework for Collaborative Work of Pathologists to Support Teaching and Research in Latin America
Early diagnosis in cancer is very important for an appropriate treatment and effective recovery in some cases. The biggest problem in develo** countries, such as Latin America, is the delay of diagnosis beca...
-
Chapter and Conference Paper
An Automatic Segmentation of Gland Nuclei in Gastric Cancer Based on Local and Contextual Information
Analysis of tubular glands plays an important role for gastric cancer diagnosis, grading, and prognosis; however, gland quantification is a highly subjective task, prone to error. Objective identification of g...
-
Chapter and Conference Paper
Flexible Architecture for Streaming and Visualization of Large Virtual Microscopy Images
The growing interest in visualization and interaction with large data has brought out the development of strategies that speed up data availability. Applications such as Virtual Microscopy are requiring effica...
-
Article
Open AccessAn oriented service multilayer architecture for virtual microscopy in mobile devices
