27 Result(s)
within
Gerhard G Thallinger
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Article
Open AccessComparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations
TP53 aberrations are found in approximately 10% of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and are considered early driver events affecting leukemia stem cells. In this stud...
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Article
Gene and miRNA expression in giant cell arteritis—a concise systematic review of significantly modified studies
Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and system...
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Article
Open AccessUtility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients
Early diagnosis and treatment of giant cell arteritis (GCA) is crucial for preventing ischemic complications. Multiple serological markers have been identified; however, there is a distinct lack of predicting ...
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Article
Open AccessCytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival
The nuclear orphan receptor NR4A1 functions as tumour suppressor in aggressive lymphomas by pro-apoptotic genomic and non-genomic effects. Here, we immunohistochemically studied the clinico-pathological relevance...
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Article
Open AccessPhylogenomics uncovers early hybridization and adaptive loci sha** the radiation of Lake Tanganyika cichlid fishes
Lake Tanganyika is the oldest and phenotypically most diverse of the three East African cichlid fish adaptive radiations. It is also the cradle for the younger parallel haplochromine cichlid radiations in Lake...
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Article
Open AccessThe mitochondrial genome of the oribatid mite Paraleius leontonychus: new insights into tRNA evolution and phylogenetic relationships in acariform mites
Bilaterian mitochondrial (mt) genomes are circular molecules that typically contain 37 genes. To date, only a single complete mitogenome sequence is available for the species-rich sarcoptiform mite order Oriba...
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Article
Deciphering lipid structures based on platform-independent decision rules
The Lipid Data Analyzer uses sets of decision rules to identify lipid subclasses in high-throughput LC-MS/MS data.
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Article
Open AccessErratum: Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily
Scientific Reports 7: Article number: 46738; published online: 03 May 2017; updated: 26 May 2017 The original version of this Article contained errors. In the Introduction section, “Finally there is a number o...
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Article
Open AccessEnzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily
Homology and similarity based approaches are most widely used for the identification of new enzymes for biocatalysis. However, they are not suitable to find truly novel scaffolds with a desired function and th...
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Chapter and Conference Paper
Topological Pathway Enrichment Analysis of Gene Expression in High Grade Serous Ovarian Cancer Reveals Tumor-Stoma Cross-Talk
Identifying the biological pathways that are significantly regulated in a given condition is a fundamental step to understanding biological phenomena. Existing pathway approaches were designed for the analysis...
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Article
Inferring expressed genes by whole-genome sequencing of plasma DNA
Michael Speicher and colleagues analyze plasma DNA whole-genome sequencing data from healthy donors and patients with cancer to infer nucleosome positioning on the basis of read depth coverage patterns. They u...
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Article
Open AccessRestoration of female fertility in Trichoderma reesei QM6a provides the basis for inbreeding in this industrial cellulase producing fungus
Filamentous fungi are frequently used as production platforms in industrial biotechnology. Most of the strains involved were known as reproducing exclusively asexually thereby preventing the application of con...
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Article
Open AccessAssessment of lipidomic species in hepatocyte lipid droplets from stressed mouse models
Lipid droplets are considered to be the hub for storage and metabolism of cellular lipids. In previous work we have phenotyped the lipidome of murine hepatocyte lipid droplets using liquid chromatography-mass ...
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Article
Open AccessA novel stable isotope labelling assisted workflow for improved untargeted LC–HRMS based metabolomics research
Many untargeted LC–ESI–HRMS based metabolomics studies are still hampered by the large proportion of non-biological sample derived signals included in the generated raw data. Here, a novel, powerful stable iso...
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Article
Open AccessEnhanced whole genome sequence and annotation of Clostridium stercorarium DSM8532T using RNA-seq transcriptomics and high-throughput proteomics
Growing interest in cellulolytic clostridia with potential for consolidated biofuels production is mitigated by low conversion of raw substrates to desired end products. Strategies to improve conversion are li...
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Article
Open AccessStenotrophomonas comparative genomics reveals genes and functions that differentiate beneficial and pathogenic bacteria
In recent years, the number of human infections caused by opportunistic pathogens has increased dramatically. Plant rhizospheres are one of the most typical natural reservoirs for these pathogens but they also...
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Article
Open AccessPeroxidase gene discovery from the horseradish transcriptome
Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of lif...
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Article
Open AccessIntegrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data
Technological improvements have shifted the focus from data generation to data analysis. The availability of large amounts of data from transcriptomics, protemics and metabolomics experiments raise new questio...
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Article
Open AccessInternational cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis
An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based on their autoantibody p...
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Chapter
High-Throughput Characterization and Comparison of Microbial Communities
The human microbiome plays an important role in health and disease, but the structure of the bacterial communities and their interaction with the human body are still poorly understood. The recent introduction...
