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  1. Article

    Open Access

    The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

    Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that contribute to accelerated memory loss and cognitive ...

    Alan D. Snow, Gerardo M. Castillo, Beth P. Nguyen, Paula Y. Choi… in Scientific Reports (2019)

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    Article

    Omeprazole and PGC-Formulated Heparin Binding Epidermal Growth Factor Normalizes Fasting Blood Glucose and Suppresses Insulitis in Multiple Low Dose Streptozotocin Diabetes Model

    Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omepr...

    Gerardo M. Castillo, Akiko Nishimoto-Ashfield… in Pharmaceutical Research (2013)

  3. Article

    Erratum to: Protected Graft Copolymer Excipient Leads to a Higher Acute Maximum Tolerated Dose and Extends Residence Time of Vasoactive Intestinal Peptide Significantly Better than Sterically Stabilized Micelles

    Sandra Reichstetter, Gerardo M. Castillo, Israel Rubinstein… in Pharmaceutical Research (2013)

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    Article

    Protected Graft Copolymer Excipient Leads to a Higher Acute Maximum Tolerated Dose and Extends Residence Time of Vasoactive Intestinal Peptide Significantly Better than Sterically Stabilized Micelles

    To determine and compare pharmacokinetics and toxicity of two nanoformulations of Vasoactive Intestinal Peptide (VIP).

    Sandra Reichstetter, Gerardo M. Castillo, Israel Rubinstein… in Pharmaceutical Research (2013)

  5. No Access

    Article

    Protected Graft Copolymer (PGC) Basal Formulation of Insulin as Potentially Safer Alternative to Lantus® (Insulin-Glargine): A Streptozotocin-Induced, Diabetic Sprague Dawley Rats Study

    To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus®, Sanofi-Aventis) with the expectation of retaining na...

    Sandra Reichstetter, Gerardo M. Castillo, ManShun Lai… in Pharmaceutical Research (2012)

  6. No Access

    Article

    Extending Residence Time and Stability of Peptides by Protected Graft Copolymer (PGC) Excipient: GLP-1 Example

    To determine whether a Protected Graft Copolymer (PGC) containing fatty acid can be used as a stabilizing excipient for GLP-1 and whether PGC/GLP-1 given once a week can be an effective treatment for diabetes.

    Gerardo M. Castillo, Sandra Reichstetter, Elijah M. Bolotin in Pharmaceutical Research (2012)