-
Article
Padded Helmet Shell Covers in American Football: A Comprehensive Laboratory Evaluation with Preliminary On-Field Findings
Protective headgear effects measured in the laboratory may not always translate to the field. In this study, we evaluated the impact attenuation capabilities of a commercially available padded helmet shell cov...
-
Article
Piecewise Multivariate Linearity Between Kinematic Features and Cumulative Strain Damage Measure (CSDM) Across Different Types of Head Impacts
In a previous study, we found that the relationship between brain strain and kinematic features cannot be described by a generalized linear model across different types of head impacts. In this study, we inves...
-
Article
Open AccessMaturation and circuit integration of transplanted human cortical organoids
Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease1–5. However, organoids lack the connectivity that exists in vivo, which limits maturation...
-
Article
Age-dependent Intracranial Artery Morphology in Healthy Children
Evaluation of intracranial artery morphology plays an important role in diagnosing a variety of neurovascular diseases. In addition to clinical symptoms, diagnosis currently relies on qualitative rather than q...
-
Article
Predictive Factors of Kinematics in Traumatic Brain Injury from Head Impacts Based on Statistical Interpretation
Brain tissue deformation resulting from head impacts is primarily caused by rotation and can lead to traumatic brain injury. To quantify brain injury risk based on measurements of kinematics on the head, finit...
-
Article
Time Window of Head Impact Kinematics Measurement for Calculation of Brain Strain and Strain Rate in American Football
Wearable devices have been shown to effectively measure the head’s movement during impacts in sports like American football. When a head impact occurs, the device is triggered to collect and save the kinematic...
-
Article
Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours
The poor transport of molecular and nanoscale agents through the blood–brain barrier together with tumour heterogeneity contribute to the dismal prognosis in patients with glioblastoma multiforme. Here, a biod...
-
Article
Open AccessMolecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma
The prognosis for high-grade glioma (HGG) remains dismal and the extent of resection correlates with overall survival and progression free disease. Epidermal growth factor receptor (EGFR) is a biomarker hetero...
-
Article
Open AccessAn epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).
-
Article
Open AccessTargeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion
Among high-grade brain tumors, glioblastoma is particularly difficult to treat, in part due to its highly infiltrative nature which contributes to the malignant phenotype and high mortality in patients. In ord...
-
Article
Open AccessSpeckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging
Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view ...
-
Article
Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries
Retrospective cohort study.
-
Article
Open AccessFirst-in-human intraoperative near-infrared fluorescence imaging of glioblastoma using cetuximab-IRDye800
Maximizing extent of surgical resection with the least morbidity remains critical for survival in glioblastoma patients, and we hypothesize that it can be improved by enhancements in intraoperative tumor detec...
-
Article
Open AccessAbstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
-
Article
Modeling and Optimization of Airbag Helmets for Preventing Head Injuries in Bicycling
Bicycling is the leading cause of sports-related traumatic brain injury. Most of the current bike helmets are made of expanded polystyrene (EPS) foam and ultimately designed to prevent blunt trauma, e.g., skul...
-
Article
Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury
We report findings from a 12-week randomized double-blinded placebo-controlled trial of methylphenidate or galantamine to treat emotional and cognitive complaints in individuals (n=32) with a history of PTSD, TBI...
-
Article
Erratum to: Six Degree-of-Freedom Measurements of Human Mild Traumatic Brain Injury
-
Article
Repeated autologous umbilical cord blood infusions are feasible and had no acute safety issues in young babies with congenital hydrocephalus
Babies with congenital hydrocephalus often experience developmental disabilities due to brain injury associated with prolonged increased pressure on the develo** brain parenchyma. Umbilical cord blood (CB) i...
-
Article
Six Degree-of-Freedom Measurements of Human Mild Traumatic Brain Injury
This preliminary study investigated whether direct measurement of head rotation improves prediction of mild traumatic brain injury (mTBI). Although many studies have implicated rotation as a primary cause of m...
-
Chapter
Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury
Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Chil...
