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  1. Article

    Open Access

    Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study

    Metabolic syndrome is considered an important risk factor for cognitive decline and dementia. However, the evidence in middle-aged individuals is still conflicting. The aim of the study was to explore the asso...

    Myrto Koutsonida, Fotios Koskeridis, Georgios Markozannes in Neurological Sciences (2023)

  2. Article

    Open Access

    Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies

    Persistent infection by oncogenic human papillomavirus (HPV) is necessary although not sufficient for development of cervical cancer. Behavioural, environmental, or comorbid exposures may promote or protect ag...

    Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes in BMC Medicine (2023)

  3. Article

    Open Access

    Sedentary behavior and cancer–an umbrella review and meta-analysis

    Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains unclear. This ...

    Rafael Hermelink, Michael F. Leitzmann in European Journal of Epidemiology (2022)

  4. Article

    Open Access

    Systematic review of Mendelian randomization studies on risk of cancer

    We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence.

    Georgios Markozannes, Afroditi Kanellopoulou, Olympia Dimopoulou in BMC Medicine (2022)

  5. Article

    Open Access

    An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites

    There is evidence that diet and nutrition are modifiable risk factors for several cancers, but associations may be flawed due to inherent biases. Nutritional epidemiology studies have largely relied on a singl...

    Nikos Papadimitriou, Georgios Markozannes, Afroditi Kanellopoulou in Nature Communications (2021)

  6. Article

    Open Access

    Awareness, knowledge and trust in the Greek authorities towards COVID-19 pandemic: results from the Epirus Health Study cohort

    To assess the level of knowledge and trust in the policy decisions taken regarding the coronavirus disease (COVID-19) pandemic among Epirus Health Study (EHS) participants.

    Afroditi Kanellopoulou, Fotios Koskeridis, Georgios Markozannes in BMC Public Health (2021)

  7. Article

    Open Access

    A survey of methodologies on causal inference methods in meta-analyses of randomized controlled trials

    Meta-analyses of randomized controlled trials (RCTs) have been considered as the highest level of evidence in the pyramid of the evidence-based medicine. However, the causal interpretation of such results is s...

    Georgios Markozannes, Georgia Vourli, Evangelia Ntzani in Systematic Reviews (2021)

  8. Article

    Open Access

    Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

    C-reactive protein (CRP) has been studied extensively for association with a large number of non-infectious diseases and outcomes. We aimed to evaluate the breadth and validity of associations between CRP and ...

    Georgios Markozannes, Charalampia Koutsioumpa in European Journal of Epidemiology (2021)

  9. Article

    Open Access

    A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

    Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration. Genetic pleiotropy occurs when a single genetic element is asso...

    Maria A. Christou, Georgios Ntritsos, Georgios Markozannes in Bone Research (2020)

  10. No Access

    Article

    Impact of heat exposure on health during a warm period in Cyprus

    People exposed to heat experience symptoms of varying severity, from mild manifestations to heat stroke. Due to global warming, interest in the impact of heat exposure on human health has been increasing. This...

    Katerina Pantavou, George Giallouros in Euro-Mediterranean Journal for Environment… (2020)

  11. Article

    Open Access

    Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies

    With the exception of renal cell carcinoma, studies assessing the association between hypertension and other cancers are inconsistent. We conducted a meta-analysis to assess this evidence. We included observat...

    Aristeidis Seretis, Sofia Cividini, Georgios Markozannes in Scientific Reports (2019)

  12. No Access

    Article

    Effects of Anabolic Androgenic Steroids on the Reproductive System of Athletes and Recreational Users: A Systematic Review and Meta-Analysis

    Anabolic androgenic steroids (AAS) are testosterone derivatives used by athletes and recreational users to improve athletic performance and/or enhance appearance. Anabolic androgenic steroids use may have seri...

    Maria A. Christou, Panagiota A. Christou, Georgios Markozannes in Sports Medicine (2017)

  13. Article

    Open Access

    An umbrella review of the literature on the effectiveness of psychological interventions for pain reduction

    Psychological interventions are widely implemented for pain management and treatment, but their reported effectiveness shows considerable variation and there is elevated likelihood for bias.

    Georgios Markozannes, Eleni Aretouli, Evangelia Rintou, Elena Dragioti in BMC Psychology (2017)