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  1. Article

    Open Access

    Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

    The insulin-like growth factor (IGF) axis has been implicated in the progression of malignant disease and identified as a clinically important therapeutic target. Several IGF-1 receptor (IGF-1R) targeting drug...

    George Vaniotis, Serge Moffett, Traian Sulea, Ni Wang, S. Mehdy Elahi… in Scientific Reports (2018)

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  2. No Access

    Article

    Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis

    Liver metastases remain a major cause of death from gastrointestinal tract cancers as well as from other malignancies such as breast and lung carcinomas and melanoma. Understanding the underlying biology is es...

    George Vaniotis, Roni F. Rayes, Shu Qi, Simon Milette, Ni Wang… in Oncogene (2018)

  3. No Access

    Protocol

    Examining the Effects of Nuclear GPCRs on Gene Expression Using Isolated Nuclei

    The measurement of changes in the transcriptome is a common end point for various pathologic and pharmacologic studies. In recent years, with the discovery of a host of potential pharmacologic targets located ...

    George Vaniotis, Sarah Gora, André Nantel… in Nuclear G-Protein Coupled Receptors (2015)